抗癫痫药卢非酰胺薄膜片的功效及副作用

Epilepsy is a clinical syndrome caused by abnormal synchronous discharge of nerves in the central nervous system. There are approximately 50 million people with epilepsy worldwide. Repeated epileptic seizures and combined cognitive dysfunction and mental abnormalities can seriously affect the patient's life and work. At present, the treatment options for epilepsy are still based on drugs. Rufinamide is a triazole derivative. The specific mechanism of action is still unclear. Studies believe that it is related to prolonging the inactivation time of Na+ channels. It was launched in Europe in 2007 and in the United States in 2008 based on a phase III clinical trial. It is currently mainly used for the treatment of Lennox-Gastant syndrome in children over 1 year old, especially the treatment of tonic or atonic seizures. Then let’s learn about the efficacy and side effects of the anti-epileptic drug rufinamide film tablets.

In a phase III randomized double-blind placebo-controlled clinical trial involving 356 patients with refractory partial epilepsy, the rufinamide group reduced seizure frequency by 23.25%, which was significantly lower than the placebo group (9.8%); the treatment group's rate of seizure reduction ≥50% (32.5%) was significantly higher than the placebo group (14.3%). The adverse reactions caused by rufinamide are similar to those of other AEDs, but it should be noted that rufinamide can cause a shortening of the Q-T interval of the electrocardiogram. The latest phase III clinical trial shows that reducing the initial dose of rufinamide and slowly increasing the dose can effectively reduce the incidence of adverse reactions without affecting the efficacy.

What were found in the experiment were drowsiness, headache, fatigue, nausea, dizziness, etc. During the period of using rufinamide, it is recommended that patients take the medication strictly in accordance with the doctor's instructions to maximize the effect of rufinamide. They must not change the medication time and dosage on their own. You must know that even if you increase the dosage of the drug, there is no way to improve the actual therapeutic effect of the drug. On the contrary, it may cause more adverse reactions, so do not use the drug blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.