喜保宁能治疗婴儿痉挛症吗？服用喜保宁有什么副作用？

Sabril (Chinese trade name: Vigabatrin) is an anti-epileptic drug. The active pharmaceutical ingredient of the drug is vigabatrin (vigabatrin). Its mechanism of action is to irreversibly inhibit GABA aminotransferase (GABA-T) and increase the concentration of GABA in the brain. Indications: As an adjunctive therapy for the treatment of adults and children (10 years and older) with refractory complex partial seizures (CPS, also known as focal seizures) who have responded inadequately to other alternative treatments and where the potential benefits outweigh the risks of vision loss. It is also indicated for the treatment of infantile spasms.

The recommended dose of Vigabatrin is 3g per day, taken in divided doses. The dose should be increased according to the clinical effect at a rate of 0.5-1g per day to 4g per day (or 50mg/kg per day), which is effective for complex partial seizures of epilepsy (with or without generalized tonic-clonic seizures). Children: General usage: For children aged 3-9 years, the recommended dose is 1g per day, divided into 2 times; for older children, 2g per day, divided into 2 times. West syndrome: Average oral dose is 100 mg/kg daily (range 50-150 mg/kg).

What are the side effects of taking Vigabatrin? : Common ones include fatigue, drowsiness, headache, dizziness, confusion and depression. Occasional aggressive behavior and psychosis (more common in patients with a history of psychosis and behavioral problems), memory loss, diplopia, weight gain, gastrointestinal disturbances, edema, and alopecia. Nystagmus, nervousness, agitation, ataxia, paresthesia, and tremor may also occur. Some patients develop irreversible visual field defects, retinal lesions such as peripheral retinal atrophy, and more rarely, optic neuritis and atrophy. Mentally, agitation, aggressive behavior, and paranoia may occur, and may occur in people with or without a history of mental illness. Mania or psychosis is also rare. Hemoglobin and transaminase values ​​may be reduced. Children may become excited and anxious.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.