非奈利酮治疗慢性肾病的效果怎么样

How effective is fenelidone in treating chronic kidney disease?

Fenelidone may have a protective effect on the heart and kidneys in patients with impaired renal function. Compared with placebo, Fenelidone significantly reduced the risk of cardiovascular composite endpoints. The FIDELIO-DKD study included 5,734 patients with diabetic nephropathy. It is a multi-center, randomized, double-blind, placebo-controlled phase III study. The results showed that with a median follow-up of 2.6 years, fenelidone could significantly reduce primary endpoint events by 18% and significantly reduce cardiovascular composite endpoint events (key secondary endpoints) by 14% compared with placebo.

In addition, fenelinone can significantly reduce non-fatal myocardial infarction by 20%. The FIDELIO-DKD study found that in patients with diabetic nephropathy, fenelinone can reduce the progression of CKD and the risk of cardiovascular events compared with placebo. Regardless of whether there is a history of cardiovascular disease, fenelidone can significantly improve cardiovascular outcomes, effectively protect cardiovascular disease, and reduce the occurrence of primary and composite endpoint events.

Advantages of Fenelidone

Fennelidone can effectively reduce serum brain natriuretic peptide levels in patients with congestive heart failure with ejection fraction and chronic kidney disease, thereby significantly reducing mortality and hospitalization rates in patients with heart failure. Before fenelinone was on the market, drugs such as spironolactone and eplerenone had been clearly proven to have beneficial effects on heart failure. Fenelidone has higher antagonistic activity on aldosterone receptors, better drug safety, and higher specificity.

Fenelidone, a new drug, has been approved for marketing in China, bringing new options to more adult patients suffering from chronic kidney disease (CKD) related to type 2 diabetes (T2D). Fenelidone is a non-steroidal mineralocorticoid receptor antagonist (MRA). It is recommended that patients take the medication under the guidance of a doctor and should not take it blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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