非奈利酮是哪个药厂生产的

Which pharmaceutical company produces Fenelidone?

Fenelidone is an imported drug developed and produced by Bayer Pharmaceuticals in Germany. Fenelidone tablets have been approved for marketing in many countries and regions, including the United States and Europe. Four months after Fenelidone tablets were approved in the EU, Fenelidone tablets were approved for marketing in China. It has brought a new treatment option to Chinese patients with chronic kidney disease related to type 2 diabetes at a global pace. It is a non-steroidal selective mineralocorticoid receptor (MR) antagonist approved for chronic kidney disease related to type 2 diabetes.

What is the mechanism of action of fenelinone

In preclinical studies, fenelinone has been shown to reduce inflammation and fibrosis mediated by MR overactivation and block the harmful effects of mineralocorticoid receptor overactivation. Fenelidone has higher binding potency and selectivity than steroidal MRA. It is a new generation of nonsteroidal MRA that does not bind to sex hormone-related receptors and has a lower incidence of hyperkalemia. It can significantly reduce the proteinuria level in patients with CKD (chronic kidney disease) combined with T2D (type 2 diabetes), while delaying the progression of kidney disease and reducing the risk of cardiovascular events.

Fenelidone, a new generation of non-steroidal highly selective mineralocorticoid receptor antagonist (MRA) independently developed by Bayer, can improve the quality of life and mainly plays an anti-inflammatory and anti-fibrotic role, thereby delaying the development of renal function and playing a dual role in protecting the heart and kidneys. It has been approved for marketing by the National Medical Products Administration on June 29, 2022.

The high selectivity and specificity of fenelidone greatly improves the effectiveness and safety of the drug. In terms of the antagonistic activity of the aldosterone receptor, the effect of fenelidone is stronger than that of spironolactone, and much higher than that of eplerenone. The above is the content of which pharmaceutical company produces fenelinone. I hope it can help you!

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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