非奈利酮有那些副作用,对肾有伤害吗？

About 40% of diabetic patients will develop diabetic nephropathy (DN), which is the main cause of CKD, and most patients die from cardiovascular diseases such as heart failure (heart failure). Blockade of mineralocorticoid receptors (MR) is an important pharmacological strategy to control blood pressure and improve heart failure and CKD. Traditional steroidal mineralocorticoid receptor antagonists (MRA) provide cardiorenal protective effects through the treatment of hypertension, heart failure and CKD, but the high incidence of hyperkalemia and other side effects limit their clinical application. At present, several new generation nonsteroidal MRAs have been developed, including finerenone, esaxerenone, aapararenone, etc. The indications evaluated include hypertension, heart failure combined with CKD and/or diabetes, and diabetic nephropathy.

Finerenone is the first new oral selective non-steroidal mineralocorticoid receptor antagonist (MRA) developed by Bayer. It was approved by the US FDA on July 9, 2021, under the trade name Kerendi. So, what are the side effects of fenelinone, and does it harm the kidneys?

What are the side effects of fenelinone?

Adverse reactions that occurred in ≥1% of patients in the fenelidone group (and occurred more frequently than in the placebo group) were hyperkalemia, hypotension, and hyponatremia.

Does fenelinone harm the kidneys?

As a new generation of mineralocorticoid receptor antagonist drug fenelidone, it can not only improve chronic kidney disease caused by type 2 diabetes

disease, and can also reduce the incidence and mortality of cardiovascular disease.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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