非奈利酮的不良反应是什么

What are the side effects of fenelinone?

Although the drug fenelinone is effective in treating heart failure in adult patients with chronic kidney disease related to type 2 diabetes, it also has adverse reactions. Common adverse reactions of fenelinone are hyperkalemia, hypotension, hyponatremia, dizziness, muscle cramps, fatigue, etc., and its safety is relatively high. However, patients' constitutions and conditions are different, and the manifestations of adverse reactions are also different. Pay attention to physical reactions during medication. If you are intolerant, contact your doctor in time for symptomatic treatment.

What were the adverse events in fenelidone clinical trials?

FIDELIO-DKD is an international multi-center randomized placebo-controlled study. In this study, the incidence of adverse events in the fenelidone treatment group was basically similar to that in the placebo group. However, in terms of hyperkalemia, the incidence of hyperkalemia was slightly increased in the fenelidone treatment group by 2.3% vs. 0.9%, but no fatal cases occurred.

Are there any contraindications to fenelidone?

Although fenelidone can be used to reduce the risk of persistent eGFR decline, cardiovascular death, end-stage renal disease, nonfatal myocardial infarction, and hospitalization for heart failure in adults with chronic kidney disease (CKD) associated with type 2 diabetes (T2D), it does have contraindications. Fennelidone is contraindicated in patients with adrenal insufficiency, and concomitant use with strong CYP3A4 inhibitors is prohibited.

Finelidone is a third-generation, potent, oral non-steroidal MRA that has higher selectivity and stronger affinity for the mineralocorticoid receptor (MR), and can block the harmful effects of MR overactivation caused by aldosterone, such as inflammation, fibrosis, etc. Fenelidone may have cardioprotective effects, particularly in patients with impaired renal function. Although fenelidone also has adverse reactions, its overall safety is good. It is recommended that patients take the drug under the guidance of a doctor and not take it blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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