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How many days should one box of fenelidone be taken?

Fenelidone, which can be used to treat diabetic nephropathy, chronic kidney disease and end-stage renal disease, is an oral drug. The recommended starting dose of fenelidone is 10 mg or 20 mg, taken orally once a day. The specifications of fenelidone include 10mg*30 tablets, 20mg*30 tablets, and 10mg*100 tablets. Different specifications and prices are also different. If it is a box of 30 tablets of 10 mg, it can be taken for about 30 days, but the patient's condition is different, and the dosage will be different. According to the eGFR and blood potassium threshold, the dosage will be increased to the target dose of 20 mg after 4 weeks, once a day. Patients can calculate the number of days they can eat from one box.

Can fenelidone be taken with food?

Fennelidone can be used to reduce the risk of persistent eGFR decline, end-stage renal disease, cardiovascular death, nonfatal myocardial infarction, and heart failure hospitalization in adults with chronic kidney disease (CKD) associated with type 2 diabetes (T2D). Fenelidone can be taken with or without food, but it must be taken according to the doctor's instructions. It cannot be taken blindly, and the dosage and usage cannot be changed at will to avoid reactions that may affect the condition.

Fenelidone can reduce proteinuria in patients and increase glomerular filtration rate. It is a non-steroidal selective mineralocorticoid receptor antagonist that can directly inhibit excessive activation of MR and reduce inflammation and fibrotic changes in the kidney and heart. In vitro tests show that the antagonistic intensity of fenelinone to aldosterone receptors is 500 times that of glucocorticoids, androgens, and progesterone.

Fenelidone was launched in China on June 29, 2022. Compared with spironolactone (first-generation MRA) and eplerenone (second-generation MRA), it has higher selectivity and stronger affinity for the mineralocorticoid receptor (MR). It is a third-generation powerful, oral non-steroidal MRA. Its function is to prevent the activity of certain steroids produced in the body. These steroids can damage the heart and kidneys.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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