托伐普坦片效果怎么样？

Hyponatremia is a common symptom in life. Treatment of hyponatremia can control the condition and prevent complications. The effect is relatively obvious. Today we will learn in detail about the effect of tolvaptan tablets?

In the phase III clinical trial, two groups were randomly assigned; one group was treated with tolvaptan 7.5 mg/d on the basis of traditional treatment, and the other group was treated with placebo for 7 days. It was statistically significant that the weight loss of tolvaptan group was more obvious on the first day after taking the drug than that of the placebo group, and this trend was maintained throughout the treatment period. The improvement rate of lower limb edema in the tolvaptan group was also significantly higher than that of the placebo group, 54.8% vs. 28.3%, P=0.0168; the change in abdominal circumference of the tolvaptan group was also significantly better than that of the placebo group, with the reduction values of abdominal circumference being (-3.38±3.56) cm and (-1.11±3.67) cm respectively, P=0.0001; there was also a significant difference in the changes in ascites volume between the two groups, placebo group vs. Tolvaptan group (-191.8±690.8) mL vs. (-492.4±760.3) mL, P=0.0093. In other words, tolvaptan is better than placebo in reducing body weight, reducing ascites volume, and improving lower limb edema.

Tolvaptan tablets are produced by Japan's Otsuka Pharmaceutical Company. Tolvaptan tablets are used to treat hypervolemic or isovolemic hyponatremia associated with heart failure, cirrhosis, and syndrome of inappropriate secretion of antidiuretic hormone. It was launched in the United States in 2009. Including upper gastrointestinal bleeding, hepatorenal syndrome, agranulocytosis, intestinal obstruction, lymphoma, liver and kidney failure and shock; heart failure, acute heart failure, multiple organ failure, drug rash, upper gastrointestinal bleeding, etc.

Tolvaptan is the first vasopressin receptor antagonist in the world. It is currently on the market in my country and can be purchased in hospital pharmacies. However, medical insurance can only reimburse part of the cost, and the financial burden is still relatively heavy. The editor recommends that patients obtain drugs through domestic professional overseas medical service agencies such as Medical Companion Travel. It is cost-effective and avoids the trouble of going abroad to purchase overseas drugs. For specific drug prices and purchase procedures, patients can consult Medical Companion Travel Service personnel.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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