托伐普坦片功效与作用

Tolvaptan tablets are a drug used to treat hypervolemic or isovolemic hyponatremia associated with heart failure, liver cirrhosis, and syndrome of abnormal secretion of antidiuretic hormone. However, many patients do not know much about it. Today, let’s take a look at the efficacy and role of tolvaptan tablets.

Tolvaptan tablets specifically antagonize arginine vasopressin and are the most common drug used to treat hyponatremia. This drug can not only control the condition but also prevent complications. Tolvaptan tablets are produced by Otsuka Pharmaceutical Company of Japan. Tolvaptan only excretes water and does not excrete sodium, so it is particularly suitable for patients with heart failure accompanied by hyponatremia.

The results of a phase III clinical trial in patients with liver cirrhosis and edema showed that one group was given placebo and the other group was given tolvaptan. The results showed that tolvaptan significantly increased serum sodium concentration and was better than placebo in terms of reducing body weight, reducing ascites, and improving lower limb edema. Tolvaptan's preclinical safety tests include single and repeated toxicity, genotoxicity, antigenicity, immunity and phototoxicity, carcinogenicity, reproductive and developmental toxicity, etc. The effects on the animal's central nervous system, respiratory and cardiovascular systems, autonomic nervous system, and digestive system have all shown safety.

The recommended starting dose of tolvaptan is 15 mg, once a day, and can be taken before or after meals. However, patients should note that changes in serum electrolytes and blood volume should be frequently detected when taking the drug for the first time and when increasing the dose. Patients should avoid restricting fluid intake during the first 24 hours of treatment and should drink water when thirsty.

Including upper gastrointestinal bleeding, hepatorenal syndrome, agranulocytosis, intestinal obstruction, lymphoma, liver and kidney failure and shock; heart failure, acute heart failure, multiple organ failure, drug rash, upper gastrointestinal bleeding, etc. During the period of taking the medicine, the patient should take it on time and in the right amount, and should not increase or decrease it at will to avoid intolerable reactions. If intolerable side effects occur, contact your doctor promptly and adopt a new treatment plan.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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