托伐普坦片治疗什么病？托伐普坦片的功效怎么样？

Tolvaptan, first approved by the FDA in May 2009, is a selective, competitive vasopressin V2 receptor antagonist developed by Otsuka Pharmaceuticals. Reduces water reabsorption by binding to V2 receptors without increasing sodium excretion. Today let’s take a closer look at what diseases tolvaptan tablets treat? How effective is Tolvaptan tablets?

The indications of Tolvaptan Tablets are for the treatment of clinically obvious hypervolemic and normovolemic hyponatremia (serum sodium concentration <125mEq/L, or hyponatremia is not obvious but symptomatic and fluid restriction treatment is ineffective). Patients with heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone secretion (SIADH) can use Tolvaptan Tablets. The drug is also called Sumac. Tolvaptan tablets are a commonly used drug in clinical practice and are used to expand blood volume. However, patients who require an urgent increase in serum sodium to prevent or treat severe neurological symptoms should not be treated with tolvaptan tablets.

In a phase III clinical trial, one group was given tolvaptan 7.5 mg/d, and the other group was given placebo for 7 days. Both were used on the basis of traditional treatment. The results showed that the improvement rate of lower limb edema in the tolvaptan group was also significantly higher than that of the placebo group, 54.8% vs. 28.3%, P=0.0168; there was also a significant difference in the changes in ascites volume between the two groups, placebo group vs. tolvaptan group (-191.8±690.8) mL vs. (-492.4±760.3) mL, P=0.0093. Changes in abdominal circumference were significantly better in the tolvaptan group than in the placebo group. This shows that tolvaptan is better than placebo in reducing weight, reducing ascites volume, and improving lower limb edema.

It is still very good. Patients should pay more attention to their own reactions during medication. If intolerance occurs, they must contact the doctor in time for symptomatic treatment. During the medication period, follow the doctor's instructions and do not change the dosage of the medication at will to avoid affecting the therapeutic effect.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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