托伐普坦片服药后有副作用吗？治疗期间需要注意什么？

Hyponatremia refers to serum sodium <135mmol/L, which is clinically common, especially in the elderly. Hyponatremia is very dangerous if it occurs within 48 hours, and convulsions, coma, respiratory arrest or death can occur quickly, which can lead to permanent neurological damage. Also called Sumac, it can be used to treat clinically apparent hypervolemic and normovolemic hyponatremia with significant efficacy.

Are there any side effects after taking tolvaptan tablets? Are the side effects serious?

Tolvaptan tablets can increase the concentration of sodium ions in plasma and help excess water be excreted from the urine. It only needs to be taken once a day. However, the drug also has side effects. Heart failure, acute heart failure, multiple organ failure, upper gastrointestinal bleeding, hepatorenal syndrome, agranulocytosis, intestinal obstruction, lymphoma, liver and kidney failure and shock, drug rash, thirst, dry mouth, fatigue, constipation, frequent urination or polyuria, hyperglycemia, etc. are the more common side effects of tolvaptan tablets. Patients need to take the medication under the guidance of a doctor to avoid intolerance reactions. Moreover, the black box warning of this product indicates that patients must take it in a hospital where blood sodium concentration is closely monitored.

What should I pay attention to during treatment with tolvaptan tablets?

Correcting the serum sodium concentration too quickly can lead to serious neurological sequelae; tolvaptan may cause irreversible and fatal liver damage; for patients with cirrhosis, this product can only be used when the benefits of treatment are judged to outweigh the risks; after taking tolvaptan tablets, obvious drainage and diuretic effects may occur; combined use with hypertonic saline is not recommended; serum potassium concentration should be monitored after the start of medication; diabetic patients receiving tolvaptan treatment should be managed with caution; there are no adequate and well-controlled studies on the use of tolvaptan tablets in pregnant women.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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