托伐普坦片副作用大不大？服用托伐普坦片需要注意什么？

Tolvaptan tablets, which inhibit the production and accumulation of cAMP, are prescription drugs and are type 2 vasopressin receptor antagonists. Tolvaptan tablets are suitable for the treatment of hyper-soluble and iso-soluble hyponatremia caused by various diseases. After 24 hours of taking the drug, the dose should be adjusted according to the serum sodium concentration. The recommended starting dose is 15 mg. So, are the side effects serious? What should I pay attention to when taking tolvaptan tablets?

Tolvaptan tablets can effectively reduce the patient's high volume (edema) condition in the long term and can effectively correct blood sodium. However, the drug also has side effects. Frequent urination or polyuria, high blood sugar, thirst, dry mouth, fatigue, constipation, heart failure, nausea, and cirrhosis are the main side effects of tolvaptan tablets. Due to different conditions of patients, the possible side effects after using tolvaptan tablets are also different. In order to improve the safety of medication, read the instructions carefully before using tolvaptan tablets and follow the doctor's instructions. This can reduce the possibility of adverse reactions.

So, what should you pay attention to when taking tolvaptan tablets? After using tolvaptan tablets, patients should be aware that correcting the serum concentration of hyponatremia too quickly (>12 mEq/L/24 hours) may lead to the risk of osmotic demyelination syndrome. Osmotic demyelination can cause spastic quadriplegia, epileptic seizures, dysarthria, dysphagia, drowsiness, emotional changes, mutism, coma, and death. Long-term use of tolvaptan tablets may cause irreversible and fatal liver damage. Only patients with cirrhosis can use the drug when the benefits of treatment are judged to outweigh the risks. Patients taking tolvaptan tablets should continue to drink fluids when thirsty. Hypertonic saline is not recommended for combined use with tolvaptan tablets.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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