西罗莫司片治疗肾移植疗效怎么样？

How effective is the treatment of kidney transplantation? As we all know, uremia is a very serious disease that can endanger people's lives, and patients must be treated in time. Kidney transplantation is a surgical method to treat uremia, but after kidney transplantation, patients will experience rejection, which will affect human health. Rapamin is a medicine used to prevent rejection reactions.

Sirolimus inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

To explore the clinical efficacy and safety of sirolimus (rapamin) in renal transplantation. Methods A total of 23 patients with cadaveric kidney transplantation from our hospital were given triple immunosuppressive therapy with this product combined with cyclosporine and glucocorticoids. Start taking this product within 48 hours after transplantation, with a loading dose of 6 mg and a maintenance dose of 2 mg.

Results: 22 patients completed 6-12 months of follow-up. The incidence rates of acute rejection (AR) at 6 and 12 months were 13.6% (3 cases/22 cases) and 15.8% (3 cases/19 cases) respectively. AR patients were reversed after methylprednisolone pulse treatment and continued to be followed up for more than half a year. No recurrence of AR was found. The main adverse reaction was hyperlipidemia (56.5%, 13 cases/23 cases). After reducing the dosage of this product or applying lipid-lowering drugs, the patient's blood lipids dropped to normal or slightly higher than normal levels. Graft vascular disease and cardiovascular complications have not increased since follow-up.

The above is the efficacy of sirolimus tablets in the treatment of kidney transplantation provided to you by our Medical Companion Overseas Medical Consulting Service Company. dIn summary, the treatment effect of kidney transplantation is ideal and it is an ideal choice for kidney transplant patients.