西罗莫司片治疗肾移植效果如何？

(sirolimus) is a triangular white or off-white sugar-coated tablet. Sirolimus tablets (sirolimus) are generally suitable for patients who have received kidney transplants to prevent organ rejection. It is recommended that sirolimus tablets (sirolimus) be used in combination with cyclosporine and corticosteroids to inhibit the production of antibodies. How effective is sirolimus tablets in the treatment of kidney transplantation? Let's take a look.

Sirolimus tablets are suitable for patients receiving kidney transplants to prevent organ rejection. It is clinically recommended to use sirolimus tablets in combination with cyclosporine and corticosteroids. This medicine should be started as soon as possible after transplantation. For new transplant recipients, the loading dose of this drug should be taken for the first time, that is, 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients.

Sirolimus oral solution is rapidly absorbed after administration, with a mean time to peak of approximately 1 hour after a single oral dose; in renal transplant recipients, the mean time to peak after multiple oral doses is approximately 2 hours. High-fat meals can increase the absorption of sirolimus, so it is recommended that oral sirolimus tablets should be taken regularly with or without food.

The above is the relevant content about the functions of sirolimus tablets. It is recommended that sirolimus tablets be used in combination with cyclosporine and corticosteroids. Sirolimus tablets are for oral administration, once daily. Sirolimus tablets should be started as soon as possible after transplantation. For new transplant recipients, a loading dose of sirolimus tablets should be taken for the first time, which is three times the maintenance dose.

(sirolimus) combined with cyclosporine and glucocorticoids can reduce the incidence of AR after kidney transplantation, and its long-term efficacy requires further observation and research.