西罗莫司片治疗效果好吗？

It is suitable for patients aged 13 or above who have received kidney transplants to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids. Are sirolimus tablets effective? Let’s take a look at the effects and functions of sirolimus tablets. Sirolimus tablets inhibit the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

Trial 1 was conducted at 38 research sites in the United States, with 719 patients participating. Randomly assigned after transplantation: 284 patients received sirolimus tablets 2 mg/day, 274 patients received sirolimus tablets 5 mg/day, and 161 patients received azathioprine 2-3 mg/kg/day. Trial 2 was conducted at 34 research units in Australia, Canada, Europe and the United States, with 576 patients participating. Randomly assigned before transplantation: 227 patients received sirolimus tablets 2 mg/day, 219 patients received sirolimus tablets 5 mg/day, and 130 patients received placebo. In both trials, antilymphocyte antibody induction therapy was contraindicated. In both trials, the primary efficacy endpoint was the rate of treatment failure within the first 6 months after transplantation. Treatment failure was defined as the first episode of acute rejection (confirmed by biopsy), graft loss, or death. Trial analysis results: Compared with azathioprine and placebo, sirolimus tablets at 2 mg/day and 5 mg/day dosage levels significantly reduced the incidence of treatment failure 6 months after transplantation.

The above is the therapeutic effect of sirolimus tablets provided by our Medical Companion Overseas Medical Consulting Service Company. The effect of treating kidney transplantation is very ideal and brings hope to patients.