How long do you usually take raloxifene hydrochloride tablets? Pharmacological effects of raloxifene

Osteoporosis is a systemic bone disease in which bone density and bone quality are reduced due to various reasons, and bone microstructure is destroyed, resulting in increased bone fragility and prone to fractures. Raloxifene is mainly used to prevent and treat osteoporosis in postmenopausal women. It can significantly reduce the incidence of vertebral fractures, but the reduction in the incidence of hip fractures has not been confirmed. Raloxifene combined with calcium preparations can prevent bone loss, maintain bone density and lower blood lipids. How long does it usually take? What are the pharmacological effects of raloxifene?

Raloxifene dosage, dosage and taking time

The recommended usage is to take 1 tablet (60 mg based on raloxifene hydrochloride) orally daily, which can be taken at any time of the day without meal restrictions. No dose adjustment is required in the elderly.

Due to the natural course of the disease, raloxifene requires long-term use. It is generally recommended that: dietary calcium, and women who do not get enough calcium take calcium and vitamin D. Or as directed by your doctor.

Pharmacological effects of raloxifene

Raloxifene is a benthiophene compound, a new concept non-hormonal drug that resists bone resorption, and is a second-generation selective estrogen receptor modulator (SERM). SERMs can act as estrogen agonists or antagonists. Raloxifene has an estrogen agonistic effect on the bones and cardiovascular system, and an estrogen antagonistic effect on the breast and uterus without many adverse reactions of estrogen. It can increase bone mineral density and prevent postmenopausal bone loss; it reduces total cholesterol, low-density lipoprotein cholesterol (LDL-C), fibrinogen and lipoprotein A levels, without affecting triglycerides and high-density lipoprotein cholesterol (HDL-C); it does not stimulate the breast and endometrium, and does not increase the risk of breast cancer and endometrial cancer.

Precautions for Raloxifene

Raloxifene is associated with an increased risk of venous thromboembolic events similar to the risks associated with currently used hormone replacement therapy. The risk-benefit balance needs to be considered in patients who may have a venous thrombotic event from any cause. Raloxifene should be discontinued in some patients who require prolonged immobilization due to illness or other conditions. Discontinue the drug immediately or 3 days before immobilization when the above conditions occur. Use should not be started again until the above situation is resolved or the patient is fully mobile.

The safety of raloxifene has not been adequately studied in patients with breast cancer. There is currently no clinical data on the use of raloxifene alone or in combination in the treatment of early or advanced breast cancer. Therefore, raloxifene can only be used for the prevention and treatment of osteoporosis after the patient has completed treatment for her breast cancer, including adjuvant therapy. Because of the lack of experience with systemic estrogens, concurrent use is not recommended.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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