Raloxifene is produced by which pharmaceutical listed company?

It is a selective estrogen receptor modulator that activates certain estrogen pathways and blocks other pathways after binding to estrogen receptors. Raloxifene reduces bone resorption and reduces biochemical markers of bone turnover to premenopausal ranges. Reduce the incidence of vertebral fractures, maintain bone mass and increase bone density. It can also affect lipid metabolism, reduce total cholesterol and LDL cholesterol levels, but does not increase triglyceride levels and has no effect on the overall HDL level.

In addition, animal experiments show that the oral bioavailability of raloxifene is 5% to 39%. Rapidly metabolized by the liver and rapidly cleared throughout the body. Glucosidase polymer, a metabolite of raloxifene, has a smaller affinity for estrogen receptors and has a smaller ability to inhibit cell proliferation than raloxifene. Oral absorption of this product is approximately 60%. It is glucuronidated in the first pass of the liver and is not further metabolized. This product is almost entirely excreted in feces. The half-life is approximately 27 hours.

Raloxifene is an anti-osteoporosis drug, mainly suitable for postmenopausal women with osteoporosis. Some studies have reported that it can significantly reduce the incidence of vertebral fractures in the spine, but there is no clear evidence that it can reduce the incidence of fractures in the hip joint and other parts. Raloxifene is an estrogen receptor modulator. After taking the drug, it can regulate estrogen levels in the body, thereby preventing osteoporosis caused by decreased estrogen levels after menopause. Therefore, it also has a good preventive and therapeutic effect on senile osteoporosis. Its adverse reactions include stomach fullness and discomfort, and in some individuals it may cause abnormalities in the cardiovascular system.

Raloxifene manufacturer: Eli Lilly Company (EliLillyCompany)

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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