非布索坦治疗痛风的疗效好吗？

Is (Febuxostat) effective in treating gout? Febuxostat (Febuxostat) is a new non-purine xanthine oxidase (XO) selective inhibitor approved for marketing. It can reduce blood urate concentration and is currently a new drug in the treatment of gout. Because of its remarkable efficacy and safety, it has been widely used in clinical research.

The "Chinese Gout Diagnosis and Treatment Guidelines (2016)" recommends that gout patients can use allopurinol (2B) or febuxostat (2B) to inhibit uric acid production, but febuxostat (febuxostat) has more advantages than allopurinol in terms of effectiveness and safety. The uric acid-lowering effect of febuxostat 40 mg/day is similar to that of allopurinol 300 mg/day. The "China Guidelines for the Diagnosis and Treatment of Hyperuricemia and Gout (2019)" recommends Febuxostat (Febuxostat) as the first-line drug for lowering uric acid in patients with gout. The starting dose is 20 mg/d, which can be increased by 20 mg/d in 2 to 4 weeks, and the maximum dose is 80 mg/d; it should be used with caution in the elderly with cardiovascular and cerebrovascular diseases; febuxostat is preferred for uric acid-lowering drugs in CKD stages 4 to 5, and the maximum dose is 40 mg/d.

The safety and efficacy of febuxostat (febuxostat) in gout were evaluated based on a multicenter, double-blind, randomized phase II clinical study. A total of 136 men and 17 women with gout were randomized to receive placebo or febuxostat (40, 80, or 120 mg/day). After 4 weeks, the test found that the serum uric acid concentration of patients in each dose group of febuxostat was significantly lower than before treatment, with an average reduction of 37%, 44% and 59% in each group from low to high doses, respectively, while the placebo group only saw a 2% reduction. The vast majority of patients persisted in completing the trial. The incidence of adverse reactions in the febuxostat and placebo groups was similar, and most of these adverse reactions were mild and self-limiting. Common ones included diarrhea, pain, back pain, headache, and joint pain.

The above is the effect of Febuxostat (Febuxostat) provided by our medical companion tour for the treatment of gout. From this point of view, the effect of (Febuxostat) is still very ideal.

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