非布索坦治疗痛风效果好吗？

Is (Febuxostat) effective in treating gout? Animal experiments show that compared with allopurinol, febuxostat is 10 to 30 times more powerful. 非布索坦（非布司他）的结构为非嘌呤类似物，故对黄嘌呤氧化酶的抑制具有选择性，对嘌呤和嘧啶代谢中的其他酶类作用很小。 Allopurinol is a purine analogue, which can affect the activity of other enzymes involved in purine and pyrimidine metabolism in the body, and is prone to some adverse reactions. The specificity of the inhibitory effect of febuxostat can avoid these possible adverse reactions. Febuxostat is completely absorbed after oral administration, with a bioavailability of approximately 85%, a peak time of approximately 1 hour, and a half-life of 5 to 8 hours. Food and antacids have no significant effect on the absorption of febuxostat.

研究结果显示，长期应用非布索坦（非布司他）可使大部分病人血尿酸长期维持在≤6.0mg/dl，肾功能轻中度损害对非布司他的药效学及药动学无明显影响，故非布司他的降尿酸作用与肾功能正常者无差异，且安全性良好。 In short, febuxostat (febuxostat) has a better uric acid-lowering effect than allopurinol without serious adverse reactions, and has good clinical application prospects.

A multicenter, double-blind, randomized phase II clinical study evaluated the safety and efficacy of febuxostat (febuxostat) in gout. A total of 136 male and 17 female gout patients were randomly assigned to receive placebo or this product (40, 80 or 120 mg/d). After 4 weeks, the test found that the serum uric acid concentration of patients in each dose group of (febuxostat) was significantly lower than before treatment, and the average decrease in each group from low to high dose was 37%, 44% and 59%, while the patients in the placebo group only decreased by 2%; the vast majority of patients persisted in completing the trial. The incidence of adverse reactions in this product and the placebo group was similar, and most of these adverse reactions were mild and self-limiting, with common ones including diarrhea, pain, back pain, headache and joint pain.

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