非布索坦的作用与服用方法

What is the function and method of taking (Febuxostat)? Let’s find out. Febuxostat (Febuxostat) is an effective non-purine selective inhibitor of xanthine oxidase XO. It achieves the therapeutic effect of reducing serum uric acid by selectively inhibiting xanthine oxidase. Uric acid is the end product of purine metabolism and is produced in the cascade reaction of hypoxanthine → xanthine → uric acid. Each step of the conversion is catalyzed by xanthine oxidase. Febuxostat (Febuxostat) has been shown to effectively inhibit both the oxidized and reduced forms of xanthine oxidase. Febuxostat (Febuxostat) at therapeutic concentrations does not inhibit other enzymes involved in purine or pyrimidine metabolism, namely guanine deaminase, hypoxanthine guanine phosphoribosyltransferase, orotate phosphoribosyltransferase, orotate monophosphate decarboxylase, or purine nucleoside phosphorylase. In addition, the U.S. Food and Drug Administration (FDA) issued a safety information warning for the gout drug Febuxostat (Febuxostat), believing that it may increase the risk of cardiovascular death and all-cause death.

How to take Febuxostat:

Febuxostat (Febuxostat) was started at 10 mg/day for 2 weeks, then increased to 20 mg/day for 4 weeks, then to 40 mg/day. Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels. Treat with febuxostat (Febuxostat) 40 mg/day for 6 months, and review uric acid levels regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body.

After 6 months of treatment: (1) If the blood uric acid level remains between 240 umol/l and 360 umol/l, maintain febuxostat (febuxostat) 40 mg/day treatment. (2) If the blood uric acid level is higher than 360 umol/l, increase the dose of febuxostat to 60 mg/day, up to a maximum of 80 mg/day, and monitor blood uric acid, liver and kidney function regularly. (3) If the blood uric acid level is lower than 240 umol/l, the dose of Febuxostat (Febuxostat) can be reduced to 20 mg/day and the treatment can be maintained for 6 months.

The above is the function and method of taking (Febuxostat) provided by our medical companion tour.

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