他克莫司胶囊(ASTAGRAFXL)正品的最新价格

Tacrolimus capsule (ASTAGRAFXL) is an immunosuppressant, mainly used to prevent organ rejection after kidney transplantation and needs to be used in combination with other immunological drugs. The drug was developed by Japan's Towa Pharmaceutical. It was launched in Japan in 1993 and entered the Chinese market in 1998 with the trade name Proximab.

The latest price of genuine tacrolimus capsules (ASTAGRAFXL)

The original drug specification of tacrolimus is 0.5mg*100 tablets, and the price is about US$110 per box. The drug is covered by China’s medical insurance, and patients can enjoy partial reimbursement with a prescription. The cost of research and development of original drugs is high, mainly because it involves clinical trials that last for several years, and imported drugs also need to bear tariffs.

Patients can purchase genuine tacrolimus through hospital pharmacies or authorized platforms. When purchasing the drug, they need to check the packaging information and expiration date, and keep the drug purchase voucher.

Guidelines for taking Tacrolimus Capsules (ASTAGRAFXL)

Tacrolimus Capsules must be taken strictly according to the doctor’s instructions. Improper dosage may cause serious side effects.

Correct time and method of taking medication

Take tacrolimus on an empty stomach every morning, and swallow the whole pill with warm water 1 hour before or 2 hours after a meal. Do not chew, crush or split the capsule, otherwise it may affect the sustained release effect of the drug.

If the missed dose does not exceed 14 hours, you can take it immediately; if it exceeds 14 hours, skip the dose and take the medicine as originally planned the next day. Do not double the dose of tacrolimus.

Blood drug concentration monitoring and dose adjustment

In the early stage of treatment, whole blood trough concentration needs to be monitored twice a week, and the target range varies depending on the treatment stage. For example, it needs to be maintained at 7-15ng/mL in the first month after surgery and dropped to 5-10ng/mL after 6 months. Patients with severely impaired liver function or those taking CYP3A inhibitors need to have their doctor adjust the dosage.

Interactions between diet and drugs

Strictly avoid grapefruit, grapefruit juice and alcohol during medication. These foods may increase drug toxicity. If you need to take other drugs such as antibiotics or antihypertensive drugs, you need to inform your doctor in advance to prevent drug interactions from affecting the efficacy.

During treatment, liver and kidney function and blood sugar levels need to be reviewed regularly, and abnormal symptoms should be reported to the doctor in a timely manner.

Who should pay attention when taking Tacrolimus Capsules (ASTAGRAFXL)

Tacrolimus may increase the risk of infection, tumors and organ damage. The following groups of people need to be particularly cautious:

Pregnant and lactating women

Tacrolimus may cause fetal malformations or premature birth, and pregnant women must strictly use contraception. If you become pregnant during treatment, you need to stop taking the medicine immediately and seek medical advice. Breastfeeding women should suspend breastfeeding to prevent drugs from affecting the baby through milk.

Patients with hepatic insufficiency

Patients with severe hepatic impairment (Child-Pugh score ≥ 10) need to reduce the starting dose and closely monitor blood drug concentrations. If jaundice or ascites worsens during treatment, you need to contact your doctor immediately to adjust the treatment plan.

Elderly patients and children

Elderly patients with reduced liver and kidney function need to lower the initial dose and extend the monitoring interval. Children over 4 years old can follow the doctor's advice and adjust the dosage according to their weight, but they need to ensure that they can swallow the capsule completely.

Tacrolimus may cause diarrhea, tremors, high blood pressure, or kidney damage. If severe headache, blurred vision or hematuria occur, stop taking the medication and seek medical advice immediately. The medicine needs to be stored in a dark place below 25°C, and after opening, keep the bottle sealed to prevent moisture.