他克莫司胶囊(ASTAGRAFXL)2025年多少钱一盒

Tacrolimus capsules are mainly used to prevent organ rejection after kidney transplantation. They were developed by Japan's Towa Pharmaceutical and entered the Chinese market in 1998. There are already generic drugs in the country. Both original drugs and generic drugs are included in the medical insurance, and patients can enjoy partial reimbursement with prescriptions.

How much does a box of Tacrolimus Capsules (ASTAGRAFXL) cost in 2025

Tacrolimus Capsules have been on the market in China for many years, and both original and generic drugs have been included in the medical insurance catalog. The reimbursement ratio varies in different regions, and patients need to consult the local medical insurance department for specific information.

The original specification of tacrolimus capsules is 0.5mg*100 tablets, and the price is about US$110 per box. The recommended starting dose for adults is 0.15-0.20mg/kg per day, which needs to be adjusted according to body weight. For example, a 60kg patient needs to take 9-12mg daily, which is about 18-24 0.5mg capsules.

In the early stage of treatment, blood drug concentration needs to be monitored weekly, with the target range being 7-15ng/mL. The dosage for children (≥ 4 years old) is calculated as 0.3mg/kg, which is determined by the doctor.

Will Tacrolimus Capsules (ASTAGRAFXL) cause side effects

Tacrolimus may cause a variety of side effects, ranging from mild discomfort to serious complications. The following are common reactions and countermeasures:

Common side effects and treatments

Diarrhea, constipation or nausea: This can be relieved by adjusting the diet (such as increasing dietary fiber), and using antidiarrheal drugs such as montmorillonite powder if necessary. If symptoms persist for more than 3 days, contact your doctor to evaluate whether the dose needs to be adjusted.

Severe side effects and emergency treatment

Increased risk of infection: When fever, cough, or wound redness and swelling occur, seek medical attention immediately and receive anti-infective treatment.

Nephrotoxicity or hypertension: Monitor creatinine and blood pressure regularly. If the values ​​increase abnormally, medication needs to be suspended and symptomatic treatment required.

Neurotoxicity (such as tremor, headache): Mild symptoms can be relieved by rest. In severe cases, the dose needs to be reduced or the drug needs to be changed.

Avoid prolonged sun exposure while taking the medicine, use SPF50+ sunscreen when going out, and undergo dermatological examinations every year. If abnormal moles or skin ulcers are found, biopsy should be performed promptly.

Tacrolimus Capsules (ASTAGRAFXL) Precautions

Correct use of medication can significantly reduce treatment risks. The following matters must be strictly observed:

Necessary preparations before medication

Patients must complete liver and kidney function, electrocardiogram and infection screening before treatment. Patients who carry the ApoEε4 gene or who use anticoagulants (such as warfarin) for a long time need additional evaluation for bleeding risk.

Dietary and drug contraindications

Do not consume grapefruit, alcohol and high-fat foods while taking the drug. These substances may increase drug toxicity. If you need to take antibiotics (such as clarithromycin) or antihypertensive drugs, you need to inform your doctor in advance to avoid drug interactions.

Restrictions on medication for special groups

Pregnant women must use strict contraception. If they become pregnant unexpectedly, they must stop taking the medication immediately. Breastfeeding women should choose formula feeding. Elderly patients need to reduce the initial dose and extend the blood concentration monitoring interval.

In daily care, patients need to maintain oral hygiene, avoid going to crowded places, reduce the risk of infection, regularly review liver and kidney function, and record changes in blood pressure and blood sugar, which will help doctors optimize treatment plans in a timely manner.