国内可以买到他克莫司胶囊(Prograf)吗

Tacrolimus capsule, also known as Prograf, Prograf, and ASTAGRAFXL, is a calcineurin inhibitor immunosuppressant, mainly used to prevent organ rejection after kidney transplantation.

Can tacrolimus capsules (Prograf) be purchased in China?

Tacrolimus capsules have been officially launched in China. The original drug is produced by Towa Pharmaceutical of Japan. The specification is 0.5mg*100 tablets and the price is about US$110 per box. It has been included in the scope of medical insurance reimbursement, and patients can purchase the drug with a doctor's prescription. Purchasing channels include hospital pharmacies that specialize in organ transplantation, large chain pharmacies, and formal online platforms. When purchasing drugs online, you need to upload a prescription.

When purchasing drugs, you need to check the drug batch number, expiration date and anti-counterfeiting label, and keep the drug purchase voucher for medical insurance reimbursement. Avoid purchasing through unauthorized channels to prevent the risk of counterfeiting.

Special medication groups for Tacrolimus Capsules (Prograf)

The risk of taking Tacrolimus capsules varies significantly among different groups, and the treatment plan needs to be adjusted individually. The following groups of people need special attention:

Pregnant and lactating women

Use by pregnant women may increase the risk of fetal malformation or premature birth, and strict contraception must be used during treatment. If you become pregnant unexpectedly, you need to stop taking the medicine immediately and seek medical advice. Breastfeeding women should suspend breastfeeding to prevent drugs from affecting the baby's development through milk.

Children and elderly patients

Children over 4 years old need to accurately calculate the dose based on body weight and ensure that they can swallow the entire capsule. Elderly patients need to reduce the initial dose by 20%-30% due to decreased liver and kidney function, and extend the blood concentration monitoring interval to once every two weeks.

Patients with hepatic and renal insufficiency

Patients with severe hepatic impairment (Child-Pugh score ≥ 10) need to reduce the starting dose by 50% and monitor blood concentration every week. Patients with renal insufficiency do not need to adjust the dose, but creatinine levels need to be closely monitored to prevent worsening of nephrotoxicity.

If hand tremors, blurred vision, or urine output decrease by more than 20% occur during treatment, you need to contact your doctor immediately to adjust your medication plan.

Daily treatment of kidney transplant patients

Long-term maintenance of immunosuppressive therapy is required after kidney transplantation. Scientific daily management can reduce the risk of complications.

Diet and Nutrition Management

Daily protein intake should be controlled at 0.8-1.0g/kg, mainly high-quality protein such as fish and chicken protein. Limit high-potassium foods (such as bananas and spinach) and limit daily salt intake to less than 5g. Use vegetable oil instead of animal oil when cooking to reduce cardiovascular burden. Avoid eating raw seafood or unpasteurized dairy products to reduce the risk of infection.

Infection Prevention and Monitoring

Avoid going to crowded places and wear a mask when going out for 6 months after surgery. The home environment is ventilated every day and tableware is disinfected at high temperature. If the body temperature continues to be higher than 38°C or cough or diarrhea occurs, you need to seek medical attention immediately to check for infection. Get inactivated influenza vaccine every year and live attenuated influenza vaccine is prohibited.

Anxiety or depression may easily occur after surgery, and family members need to listen patiently and provide emotional support. You can join a mutual support community for transplant patients and share recovery experiences. Patients can engage in low-intensity exercise for 30 minutes a day and avoid heavy lifting or strenuous exercise. Keep your sleep time to 7-8 hours and avoid staying up late.