地舒单抗治疗期间要注意什么？

, which was used to treat osteoporosis in the early days and was later found to be able to treat giant cell tumors of bone. Preventing the growth of osteoclasts and combining with surgical treatment have reduced the recurrence rate. So, what should we pay attention to during treatment with denosumab?

(1) Do not use the same active drug: patients taking denosumab should not use denosumab.

(2) Allergic reactions may occur when using denosumab; if allergic reactions occur, the medication should be discontinued permanently.

(3) Hypocalcemia: Desosumab may cause severe symptoms of hypocalcemia, or be fatal. Hypocalcemia should be corrected before medication, and the patient's blood calcium level should be monitored during treatment, especially in the first week of first medication, and calcium and vitamin D should be supplemented appropriately.

(4) Osteonecrosis of the jaw (ONJ): Osteonecrosis of the jaw (ONJ) has been reported. Oral examination should be performed before medication, symptoms should be observed during treatment, and any invasive dental procedures should be avoided.

(5) Atypical femoral fracture: Assess the patient’s thigh or groin pain to diagnose atypical femoral fracture.

(6) Hypercalcemia after discontinuation of medication: Monitor patient’s symptoms and treat appropriately.

(7) Embryo-fetal toxicity: Desosumab harms the fetus. Women of childbearing age should be informed of the dangers of this drug and take effective contraceptive measures.

In addition, patients should also note that if any of these symptoms occur during or after taking the medication, please tell your doctor immediately:

Cramps, muscle twitching, muscle spasms, numbness or tingling around the fingers, toes, or mouth and/or seizures, confusion, or loss of consciousness. These may be signs of low calcium levels in the blood. Low levels of calcium in the blood may also cause a change in heart rhythm, called QT prolongation, which can be seen on an electrocardiogram (ECG).

Tell your doctor right away if any of these symptoms occur while you are on treatment or after stopping treatment: pain in the mouth and/or jaw, swelling or non-healing sores in the mouth and/or jaw, swelling or loosening of teeth in the mouth and/or jaw, non-healing sores in the mouth or jaw, discharge, numbness, or a heavy feeling, which may be a sign of damage to the jawbone (osteonecrosis).