地舒单抗如何购买？

For the prevention of bone-related events in patients with bone metastases from solid tumors.

Desosumab is the first approved monoclonal antibody that specifically targets RANK ligand. RANK ligand is a transmembrane or soluble protein that is necessary for osteoclasts to maintain their structure, function, and survival. Human RANKL mRNA is mainly found in bones, bone marrow and lymphoid tissues. Its main function in bones is to stimulate the differentiation and activity of osteoclasts and inhibit the apoptosis of osteoclasts.

So, how to buy denosumab?

Purchasing channels for denosumab: In May 2019, denosumab was conditionally approved for marketing. However, because it was conditionally approved and only available for five months, it is difficult to buy it in China.

Fortunately, Desosumab produced by Amgen in the United States is already on the market. The specification is 125mg/1ml tube/box. The price is equivalent to RMB 3,000. It can be said to be high-quality and low-priced, and it is also the most commonly used drug on the market!

If you need denosumab but do not want to go abroad, the most reliable way is to purchase it through a regular domestic overseas medical service institution, which will sign a guarantee contract for you. The drug and drug payment will not be handled by you, and it will be mailed to the patient by direct mail, guaranteed to be 100% authentic!

Adverse effects of using denosumab (Xgeva):

The most common adverse reactions in patients with solid tumor bone metastases are fatigue/asthenia, hypophosphatemia, and nausea.

Common adverse reactions in patients with giant cell tumor of bone include headache, joint pain, nausea, back pain, fatigue and pain in the extremities.

Adverse effects of malignant hypercalcemia include nausea and vomiting, dyspnea, decreased appetite, headache, peripheral edema, anemia, diarrhea, and constipation.

The most common adverse reactions (≥10%) with use in multiple myeloma are diarrhea, nausea, anemia, back pain, thrombocytopenia, peripheral edema, hypocalcemia, upper respiratory tract infection, rash, and headache.