地舒单抗是什么药物呢？

What kind of medicine is it? The following is an introduction to the drug denosumab:

Indications for denosumab:

1. Prevent skeletal-related events in patients with multiple myeloma and patients with bone metastasis from solid tumors.

2. Treat adult patients with giant cell tumors of bone who are not suitable for surgery and have mature skeletal systems.

3. Treatment of hypercalcemia of malignant tumors that are resistant to bisphosphonates.

4. It is not used to treat patients with multiple myeloma and prevent their bone-related symptoms.

Desosumab is a drug that targets the RANK ligand. Compared with bisphosphonates that have been used clinically, denosumab has the advantage of significantly prolonging the occurrence time of bone damage-related events. It can be administered subcutaneously and is easy to use. Clinical data shows that the drug does not require monitoring of renal function, while the use of bisphosphonates must be based on the patient's renal function monitoring. The dosing speed must be determined.

Things to note when using denosumab:

1. Hypocalcemia must be corrected before denosumab treatment is started. For patients who are prone to hypocalcemia and mineral metabolism imbalance (such as those with a history of hypoparathyroidism, thyroid surgery, parathyroid surgery, malnutrition, small bowel resection, severe renal insufficiency), clinical monitoring of creatinine and mineral levels (such as phosphorus and magnesium) is required, and such patients should be instructed to pay attention to the symptoms of hypocalcemia and to supplement adequate amounts of calcium and vitamin D.

2. Patients who are concurrently taking immunosuppressants or have compromised immune systems may have an increased risk of serious infections. Physicians must fully consider the benefit-risk ratio before prescribing denosumab to such patients. For patients who develop serious infections while taking denosumab, physicians should evaluate the need to continue denosumab therapy.

3. Osteonecrosis of the mandible (which can occur spontaneously) is usually accompanied by tooth extraction and local infection that delays healing. A routine oral examination should be performed before starting treatment, and good oral hygiene should be maintained after treatment begins. If a patient develops osteonecrosis of the jaw, treatment for osteonecrosis of the jaw may worsen the condition, and discontinuation of the medication should be considered at this time.