罕见病治疗药物氨己烯酸片的效果

(Vigabatrin) is an analog of gamma-aminobutyric acid (GABA). It can specifically bind to GABA aminotransferase and irreversibly, leading to an increase in GABA concentration in the brain, thereby exerting anti-epileptic effects. Vigabatrin tablets (vigabatrin) are clinically used to treat epilepsy in which other anti-epileptic drugs are ineffective, especially partial seizures, and can also treat infantile spasms (West syndrome, West syndrome).

The effect of the rare disease treatment drug vigabatrin tablets: A clinical trial explores the therapeutic effect of the rare disease drug vigabatrin (vigabatrin) on refractory epilepsy in children. The efficacy and safety of vigabatrin tablets (vigabatrin) on 25 children were observed using the method of drug augmentation test. Two months after taking the medicine, the total effective rate was 68.0%. There were 24 patients who took the medicine for ≥4 months, and the total effective rate was 70.8% (21/24).

After taking vigabatrin tablets, the blood concentration of phenobarbital is lower than before taking the drug. The serum alanine aminotransferase level was lower than before taking the medicine. No side effects were seen in 32 cases. 2 cases developed mild dizziness and drowsiness in the early stage after taking the medicine, which were relieved by themselves; 1 case developed severe restlessness and terminated treatment. Observation results show that vigabatrin tablets (vigabatrin) are more effective in treating refractory epilepsy in children and have less adverse side effects.

Patients who are treated with vigabatrin tablets (vigabatrin) should pay attention to:

Vigabatrin should be used under the guidance of an epilepsy specialist or child neurologist. Reactions after taking the medication should be reported to the doctor promptly.

The incidence of visual field defects is high (approximately one third) in patients taking vigabatrin. This often occurs after several months to years of using vigabatrin. Visual field defects can be severe, which can have real consequences for the patient. Most patients with visual field loss have no obvious symptoms.

The above is the introduction about (vigabatrin), I hope it can help everyone. If patients have other questions about the drug (such as drug price, purchasing channels, etc.), they can consult the medical companion travel service.

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