氨己烯酸片(喜保宁)是靶向药吗

(Vigabatrin) is used as adjuvant therapy for the treatment of patients who are refractory to other anti-epileptic drugs, especially those with partial seizures (mainly used to control complex partial seizures).

A clinical trial explores the therapeutic effect of the rare disease drug Vigabatrin Tablets (Vigabatrin) on refractory epilepsy in children. The efficacy and safety of vigabatrin tablets (Vigabatrin) on 25 children were observed using the method of drug augmentation test. Two months after taking the medicine, the total effective rate was 68.0%. There were 24 patients who took the medicine for ≥4 months, and the total effective rate was 70.8% (21/24).

Experimental method: 10 children with TSC and IS who were treated with vigabatrin (500-1750 mg/d) from February 2013 to July 2015 were collected, their treatment conditions were retrospectively analyzed, and their clinical efficacy and adverse reactions were observed. Results The cumulative application time of vigabatrin in this group ranged from 1 to 49 months, with a median time of 10 months. After diagnosis, 2 cases were treated with vigabatrin tablets (Vigabatrin) as the first choice, and Yu was treated with vigabatrin tablets (Vigabatrin) after being dissatisfied with other drug treatments. Among them, 8 cases of spasm disappeared or were close to disappearing, 1 case did not improve, and 1 case improved after adding adrenocorticotropic hormone. 6 cases took effect within 1 week, 1 case took effect on 15 days and 60 days respectively, and the average onset of effect was 5 days. The drug was well tolerated in 10 cases and the adverse reactions were mild.

The use of vigabatrin tablets (Vigabatrin) should be carried out under the guidance of an epilepsy expert or a child neurologist. Reactions after taking the medication should be reported to the doctor promptly. Vigabatrin tablets (Vigabatrin) are oral medicines that can be taken once or twice a day, before or after meals. It is advisable to drink half a glass of water when taking the medicine.

If your epilepsy condition does not improve after taking it for enough time, you should stop taking Vigabatrin. At this time, vigabatrin tablets (Vigabatrin) should be gradually stopped under the supervision of a doctor.

Adult dosage: The maximum dosage of vigabatrin tablets (Vigabatrin) is 2-3 grams per day. It is appropriate to start taking it at 1g a day, and then according to the reaction after taking the medicine, if the reaction is good, it can be increased by 0.5g every week. Finally, the daily dosage is reached 2-3g. The maximum daily dosage should not exceed 3g.

Practice shows that visual field defects are irreversible even if you stop taking Vigabatrin. Therefore, the risks and benefits of treatment must be weighed carefully.

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