氨己烯酸片(喜保宁)卖多少钱

On August 21, 2009, the U.S. FDA approved Sabril as a monotherapy for pediatric patients 1 month to 2 years old, where the potential benefits of infantile spasms outweigh the potential risk of vision loss, and as an adjunctive (additional) treatment (CPS) for adult patients with refractory complex partial epilepsy. On January 16, 2019, the FDA approved the launch of a generic version of Vigabatrin.

The editor learned that the specifications of vigabatrin tablets (Vigabatrin) produced by Sanofi in France are 500mg*100 tablets, and the price is around 1,500$. The price may change due to various factors such as exchange rates. Patients can consult the medical companion passenger service for specific prices and related issues.

Vigabatrin tablets (Vigabatrin) are an anti-epileptic drug with an obvious mechanism of action. Treatment with vigabatrin tablets (Vigabatrin) will cause an increase in the concentration of GABA (gamma-aminobutyric acid), which is the main substance that inhibits neurotransmitters in the brain. This is because Vigabatrin is an irreversible inhibitor of GABA transaminase, which is a substance that breaks down GABA. The decrease in GABA transaminase will inevitably lead to an increase in GABA concentration.

Long-term clinical follow-up shows that when conventional drug therapy does not have a good effect on epilepsy, using vigabatrin tablets (Vigabatrin) as an auxiliary treatment agent is an effective method. Especially for patients with mild epilepsy, the effect is better.

Vigabatrin tablets (Vigabatrin) are water-soluble compounds that can be rapidly and completely absorbed by the intestines. Diet will not affect the absorption of Vigabatrin tablets. After taking Vigabatrin tablets, it will be widely distributed throughout the body, and the apparent distribution amount is slightly larger than the distribution of water in the body. There is no direct relationship between the concentration of a drug in the blood and its effectiveness. The duration of drug effect depends on the GABA transaminase resynthesis rate. The half-life of vigabatrin tablets (Vigabatrin) in the blood for digestion and absorption is 5 to 8 hours. Within 24 hours after a single dose, 70% of the drug's components in urine tests remain unchanged, and no metabolites are detected. Vigabatrin does not induce the production of hepatic cytochrome P450 enzymes, nor does it affect protein binding, so there is no interaction between drugs.

At this stage, experimental research on (Vigabatrin) has not found that it has mutagenic or carcinogenic effects.

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