喜保宁是什么药？治什么病？

What kind of medicine is Vigabatrin? What disease does it cure? Vigabatrin Sabrilex is an oral drug that was developed in the 1980s. Vigabatrin Sabrilex is a synthetic derivative of gamma-aminobutyric acid (GABA). It increases the concentration of the inhibitory neurotransmitter GABA in the brain by irreversibly inhibiting GABA aminotransferase. It can increase the level of GABA in the human brain as the activity of GABA aminotransferase continues to decrease rapidly, and there is an obvious dose-effect relationship. Studies have shown that after administration of vigabatrin, the concentration of GABA in the brains of rodents and the cerebrospinal fluid of humans increases, and the degree of increase is dose-related. In 2009, vigabatrin was approved for marketing in the United States. Its indication is the treatment of epilepsy in which other anti-epileptic drugs are ineffective, especially partial seizures. Vigabatrin can also treat infantile spasms (West syndrome, West syndrome).

Sabrilex is administered orally. The maximum daily dose for adults is 2-3g. When starting to take Sabrilex, 1g per day is appropriate. Then, depending on the response after taking the medication, if the response is good, it can be increased by 0.5g per week, and finally reaches a dosage of 2-3g Sabrilex per day. The use of vigabatrin should be done under the guidance of an epilepsy expert or a child neurologist. Reactions after taking the medication should be reported to the doctor promptly.

There are some common side effects of vigabatrin treatment, including: fatigue/drowsiness/dizziness/headache/confusion and depression. Occasional aggressive behavior and psychosis (more common in patients with a history of psychosis and behavioral problems)/double vision/memory loss/gastrointestinal disturbances/weight gain/edema and hair loss. Neurosis/nystagmus/irritability/ataxia/paresthesia/tremor may also occur. The toxic effects of vigabatrin on the retina may lead to peripheral visual field defects in children, so regular ophthalmological monitoring is required. Since each patient's physical condition is not exactly the same, the degree of side effects of using vigabatrin is not exactly the same. If serious side effects occur, please contact your doctor in time.

The above is the introduction about Sabrilex. If patients have other questions about vigabatrin (such as drug prices, purchase channels, etc.), they can consult the medical companion travel service.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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