喜保宁(氨己烯酸片)效果怎么样？

Vigabatrin Sabrilex is an anti-epileptic drug. The indications of Vigabatrin (vigabatrin tablets) include: auxiliary treatment of anti-epilepsy; Vigabatrin (vigabatrin tablets) can be used as an auxiliary treatment for partial seizures of refractory complex epilepsy; Vigabatrin Sabril can also be used to treat infantile spasms and Lennox-Gastaut syndrome; Vigabatrin Sabril can be used for tardive dyskinesia. Vigabatrin (vigabatrin tablets) is clinically used to treat epilepsy in which other anti-epileptic drugs are ineffective, especially partial seizures, and can also treat infantile spasms (West syndrome, West syndrome). It is a drug used to treat epilepsy and infantile spasms, developed in the 1980s.

How effective is Vigabatrin (vigabatrin tablets)?

Among pediatric patients, 135 children aged 2 months to 12 years old with intractable epilepsy were treated with vigabatrin tablets. The effective rate was 34%, of which 49% were effective for partial seizures and only half of that for generalized seizures. There were 13 cases of infantile spasms and 26 cases of Lennox-Gastaut syndrome. Symptomatic childhood spasticity is better treated than cryptogenic spasticity.

Clinical trials explore the therapeutic effect of the rare disease drug Vigabatrin (vigabatrin tablets) on refractory epilepsy in children. The drug-increasing test method was used to observe the efficacy and safety of the drug on 25 children. Two months after taking the medicine, the total effective rate was 68.0%. There were 24 patients who took the medicine for ≥4 months, and the total effective rate was 70.8%. After administration of vigabatrin, phenobarbital blood concentrations are lower than before administration.

The serum alanine aminotransferase level was lower than before taking the drug. There were no toxic or side effects in 32 cases. 2 cases developed mild dizziness and drowsiness in the early stage after taking the medicine, which resolved spontaneously. 1 case developed severe restlessness and terminated treatment. Observation results show that Vigabatrin (vigabatrin tablets) is more effective in treating refractory epilepsy in children and has mild side effects.

Vigabatrin (vigabatrin tablets) is rapidly absorbed after oral administration, and food does not affect its absorption rate. The peak plasma concentration is reached 2 hours after taking the drug, and t1/2 is 5-7 hours. When a single dose is 1-3g, the pharmacokinetics show a dose-linear relationship. If the patient has special circumstances, he or she needs to inform the doctor before starting treatment with Vigabatrin (vigabatrin tablets). The doctor will make adjustments to the patient's medication based on the actual situation to avoid harm to the patient due to incorrect medication.

The above is the introduction about). If patients have other questions about vigabatrin (such as drug prices, purchasing channels, etc.), they can consult the medical companion travel service.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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