苯巴那酯一天吃几次？苯巴那酯（Ontozry）治疗效果怎么样？

The U.S. Food and Drug Administration (FDA) has approved the marketing of Phenomenate (Ontozry) in 2019 for the treatment of partial-onset epilepsy in adults. This drug is a sodium channel (sodium channel) blocker. Today let’s take a detailed look at how many times a day should you take Phenobarate? (Ontozry) How effective is the treatment?

Ontozry can be taken with or without food, but it needs to be taken with water and not chewed. Recommended initial dose: 12.5 mg once daily during weeks 1 and 2; maintenance dose: 200 mg once daily during weeks 11 and thereafter; for patients with mild to moderate hepatic impairment (liver function assessment 5-9 points), the maximum recommended dose is 200 mg once daily. Patients should not increase or decrease the dose at will, follow the doctor's instructions, read the instructions carefully before taking the medication, and treat the symptoms accordingly.

So, what is the therapeutic effect of Ontozry? Study 017 included a 6-week titration period and a 12-week maintenance period. The study included doses of 100 mg/day, 200 mg/day, and 400 mg/day of phenobarnate, the data show. , three doses of phenobarate reduced the median seizure frequency by 36%, 55%, and 55% respectively, and the placebo group reduced it by 24%. The data had statistically significant differences; during the maintenance period, 4%, 11%, and 21% of patients in the three dosage groups reported zero seizures, respectively, and 1% in the placebo group. The Study 013 study included a 6-week titration period and a 6-week maintenance period. The data showed that phenobarnate reduced the median seizure frequency by 56%, with 28% of patients in the phenobarnate treatment group reporting zero seizures; while in the placebo group, the median seizure frequency was reduced by 22%, and 9% of patients reported zero seizures.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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