5分钟带你了解卢非酰胺的功效及副作用

Epilepsy is a common neurological disease, with more than 50 million people suffering from epilepsy worldwide. During an epileptic seizure, abnormal nerve discharges cause an increase in the synchrony of brain electrical activity, leading to a brief functional disability in the patient. Epilepsy not only causes physical disorders, but also affects the patient's mental health. The premature mortality rate of patients is three times that of the general population. Currently, rufinamide is very popular in the treatment of epilepsy. Today I will take 5 minutes to tell you about its effects and side effects.

Rufinamide is a new anti-epileptic drug of the triazole derivative class, which can limit nerve sodium ion-dependent action potentials and stabilize cell membranes. Studies have found that the highest daily dose of rufinamide (3200 mg) can effectively control the seizures of refractory partial-onset epilepsy and that most patients tolerate this dose well. However, a large-scale clinical randomized controlled study included a total of 357 patients and randomly divided them into the rufinamide group and the placebo control group. The results found that rufinamide could significantly reduce the monthly frequency of partial-onset epilepsy (23.25 vs 9.8; P=0.007). The proportion of epilepsy patients in the rufinamide group who reduced the weekly seizure frequency by >50% was significantly higher than that in the placebo control group (32.5% vs 14.3%; P<0.001).

Those found in studies were headache, dizziness, fatigue, drowsiness and nausea. If you are currently using rufinamide, the editor here recommends that patients must take the correct medication according to the doctor's instructions. Some patients always think that simply increasing the dosage of the drug can improve the effect of the drug itself, and they also think that simply reducing the dosage of the drug can reduce the occurrence of side effects. However, this is not actually the case. If the dosage of the drug is changed privately, it may cause more adverse reactions, so do not use the drug blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.