呲仑帕奈片副作用有哪些

Many people know that epilepsy is an imbalance between excitation and inhibition. If there is insufficient inhibition or too much excitement, epilepsy can occur. In the past, many antiepileptic drugs have been associated with two main mechanisms. One is membrane stabilization, a mechanism through which sodium channel blockers work. Another mechanism is increased inhibition, thereby preventing the development of epilepsy. Likening a seizure to a fire, increasing GABA in the brain is like putting a blanket over the brain. Valproic acid works partly through this mechanism, but the main drugs that act through this mechanism are vigabatrin and tiagabine. Another mechanism for extinguishing fire is to prevent it from obtaining fuel, which is similar to reducing excitement. It works by reducing fuel: reducing signaling at receptors for the excitatory neurotransmitter AMPA that mediates the stimulating effects of glutamate.

What are the side effects of Parampanel Tablets? : The most common adverse reactions of valampanel reported in adverse reaction regulatory trials are dizziness, drowsiness, fatigue, irritability, nausea, falls and weight gain. At the same time, the biggest problem with the use of parampanel is that at daily doses of 8 mg or more, parampanel can easily cause or worsen mental and behavioral adverse events, especially anger, hostility, and aggression.

Regarding changes in cognitive function, a study in the United States and the United Kingdom conducted a follow-up assessment of cognitive function in 12 to 18-year-old patients with focal epilepsy treated with parampanel. The results showed that there was no difference in overall cognitive scores between the parampanel treatment group and the placebo group, but there were subtle differences in some other areas: Compared with the placebo group, patients treated with parampanel showed some improvement in episodic memory ability, but their continuous attention and memory speed declined. Overall, parampanel has less impact on cognitive function in children. Finally, the editor recommends that patients who have serious adverse reactions during medication should go to the hospital for examination in time and consult relevant doctors to determine follow-up treatment plans.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.