氨己烯酸口服溶液用散的不良反应有哪些

Vigabatrin oral solution powder is suitable for pediatric patients with infantile spasms between 1 month and 2 years old. Its potential benefits outweigh the potential risks of vision loss. It is the first-line treatment for infantile spasms (IS). Although the treatment effect is significant, it also has adverse reactions.

In a U.S. and primarily non-U.S. clinical study of 4,079 vigabatrin-treated patients, the most common (>5%) adverse reactions associated with vigabatrin use in combination with other AEDs (antiepileptic drugs) were headache, somnolence, fatigue, dizziness, convulsions, nasopharyngitis, weight gain, upper respiratory tract infection, visual field defects, depression, tremor, nystagmus, nausea, diarrhea, memory impairment, insomnia, irritability, coordination abnormalities, blurred vision, diplopia, vomiting, Flu, fever and rash.

The adverse reactions most commonly associated with discontinuation of treatment were convulsions and depression in >1% of patients.

The adverse reactions most commonly associated with discontinuation of vigabatrin therapy in patients with infantile spasms, occurring in >1% of patients, are infection, status epilepticus, developmental coordination disorder, dystonia, hypotonia, hypertonia, weight gain, and insomnia.

In a randomized, placebo-controlled IS study with a 5-day double-blind treatment phase (n=40), adverse reactions that occurred in >5% of patients receiving vigabatrin and more frequently than in patients receiving placebo were somnolence (vigabatrin 45%, placebo 30%), bronchitis (vigabatrin 30%, placebo 15%), ear infection (vigabatrin 10%, placebo 10%) 5%) and acute otitis media (vigabatrin 10%, placebo 0%).

In dose-response studies of low-dose (18 to 36 mg/kg/day) versus high-dose (100 to 148 mg/kg/day) vigabatrin, no clear correlation between dose and incidence of adverse reactions was observed.

If symptoms such as nystagmus, nausea, and vomiting occur after taking vigabatrin oral solution, you should stop using the drug immediately and go to a regular hospital for treatment to avoid delaying the condition and affecting your health. It is recommended that patients pay attention to physical reactions during medication. If there is intolerance, contact the doctor in time for symptomatic treatment. For more information about vigabatrin oral solution powder, you can read the drug instructions.

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