服用抗癫痫药物苯巴那酯(cenobamate)期间应注意什么？

Cenobamate is an anti-epileptic drug used to treat partial seizures. While taking Phenobarate, patients should follow the doctor's instructions, not stop taking the drug or change the dosage without authorization, be aware of possible side effects, avoid using it at the same time with alcohol and other drugs, and avoid driving and operating machinery.

follow your doctor's instructions

During treatment with cenobamate, patients should ensure that they use cenobamate in accordance with the doctor's instructions and prescriptions, including dosage and taking time, to avoid inappropriate use of the drug that may affect their health.

Patients should be aware that clinical experience with cenobamate overdose in humans is limited, and there is no specific antidote for cenobamate overdose. In the event of an overdose, any standard medical practice for overdose management should be used. Adequate airway, oxygenation, and ventilation should be ensured, and monitoring of heart rate, rhythm, and vital signs is recommended. A certified poison control center should be contacted for the latest information on cenobamate overdose management.

Do not stop taking medication or change dosage without permission

As with most antiepileptic drugs, they should usually be discontinued gradually because of the risk of increased seizure frequency and status epilepticus. However, if treatment needs to be discontinued due to serious adverse events, rapid discontinuation may be considered. Therefore, do not stop using cenobamate or change your dose unless directed by your doctor.

know the possible

Cenobamate may cause a series of side effects, including headache, dizziness, drowsiness, difficulty concentrating, insomnia, pharyngitis, urinary tract infection, nausea, dysmenorrhea, decreased appetite, musculoskeletal pain, dizziness, brain injury, indigestion, vomiting, etc. If you experience side effects while using phenoparate, you can take the following steps to deal with it:

1. Communicate with your doctor: If you experience any side effects, you should first communicate with your doctor. Your doctor may evaluate your symptoms and provide further guidance and advice as needed.

2. Adjust dosage: In some cases, side effects may be related to drug dosage. If the side effects are mild, your doctor may recommend adjusting the dose to lessen the side effects.

3. Persist in use: Some side effects may appear when you start using cenobamate, but they will gradually reduce or disappear over time. In this case, it may be reasonable to stick with the medication, but decide with your doctor.

Avoid alcohol and other drugs

Because alcohol and some other drugs may interact with cenobamate, the risk of adverse neurological effects may be increased, including sedation and drowsiness. Therefore, avoid drinking alcohol and taking other medications while taking Phenomenate, unless approved by your doctor.

avoid pregnancy

Cenobamate may have adverse effects on the fetus. In animal studies, administration of cenobamate during pregnancy or throughout pregnancy and lactation has been associated with adverse developmental effects (increased embryonic mortality, decreased fetal and offspring body weight, offspring neurobehavioral and reproductive impairment) at clinically relevant drug exposures.

If you are planning to become pregnant or are pregnant, tell your doctor and they will evaluate whether it is appropriate to continue using cenobamate based on your individual circumstances.

Drive and operate machinery with caution

Cenobamate may cause drowsiness and difficulty concentrating, affecting your ability to react. Before you start using cenobamate, you should understand how this drug may affect your driving and operating machinery, and take appropriate precautions if needed.

Use with caution in patients with liver and kidney damage

Cenobamate should be used with caution in patients with renal impairment, and dose reduction may be considered in patients with mild to moderate (CLcr30 to less than 0/min) and severe (CLcr less than 30mL/min) renal impairment. Not recommended for use in patients with end-stage renal disease receiving dialysis. Cenobamate should also be used with caution in patients with hepatic impairment and for use in mild to moderate (Child-Pugh assessment score 5-9: Class A or B) hepatic impairment. For these patients, the maximum recommended dose is 200 mg once daily, and further dose reductions may be considered. Cenobamate is not recommended for patients with severe hepatic impairment.

Summary

The above are just some general precautions. Patients should follow the doctor's advice and guidance to determine the precautions suitable for your personal situation. If you have any questions or concerns, further discussion and consultation with your doctor is recommended.

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