苯巴那酯(cenobamate)能降低癫痫发作频率吗？

Can reduce the frequency of epileptic seizures.

In clinical studies, phenobarnate resulted in a baseline seizure frequency of 8.5 seizures/28 days. The trial results showed that compared with baseline levels, different doses of phebanate reduced the frequency of epilepsy in patients by 36% (100mg), 55% (200mg), and 55% (400mg) respectively.

Phenobarnate market status

On November 21, 2019, Phenobarate was approved by the US FDA for the treatment of partial-onset epilepsy in adults.

On December 7, 2022, phenoparate was launched in France and Belgium.

On January 22, 2024, Phenobarate was launched in Canada.

The mechanism of action of Phenobarate

1. Block sodium channels: Phenobarate can inhibit the sodium channels of nerves, reduce the excitability of nerves, thereby reducing the discharge frequency of nerves, and help control epileptic seizures.

2. Positive allosteric regulation of GABA receptors: Phenobarate can regulate γ-aminobutyric acid (GABA) receptors through positive allosteric regulation, enhance the inhibitory neurotransmitter effect of GABA, and further reduce the excitability of nerves.

3. Inhibition of NMDA receptor inhibition: Phenobanate may also have the effect of reducing the activation of NMDA-type glutamate receptors, which helps reduce neural excitability because NMDA receptors play a key role in epileptic seizures.

Phenobamate (cenobamate) reduces seizure frequency

In an 18-week study (6-week titration phase and 12-week maintenance phase), participants took cenobamate or a placebo added to anti-epileptic drugs to treat partial seizures. Patients with epilepsy treated with phenobarnate were effective in reducing epileptic seizures, reducing seizure frequency by 55% compared to placebo.

In clinical trials, 28% of patients taking 400 mg of Phenobarate experienced a 90% reduction in seizures, while only 3% of patients taking a placebo experienced a 90% reduction in seizures.

Phenobarnate makes it possible to achieve zero seizures, and 1 in 5 people achieve zero seizures with phenobarate.

Medication Guide

The dosage of Phenobarate will vary for different patients, and you should follow your doctor's instructions or the directions on the label. The following information includes only average doses of this drug.

For partial seizures, the recommended dose for adult patients is 12.5 mg once a day for 2 weeks. Your doctor may gradually increase the dose every two weeks, but the dose usually does not exceed 400 mg per day.

Reference price of Phenobarate

1. 12.5mg*28 capsules: the reference price of a box is about 1500$-2200$.

2. 25mg*28 capsules: The reference price of a box is about 1500$-2200$.

3. 50mg*84 capsules: The reference price of a box is about 3800$-4500$.

4. 50mg*28 capsules: The reference price of a box is about 1680$-2500$.

5. 50mg*14 capsules: the reference price of a box is about 850$-1200$.

Summary

Phenobarnate is a new anti-epileptic drug used to treat focal epilepsy in adults. In clinical trials, phebanate showed efficacy in reducing the frequency of epileptic seizures. Phenobarate should be taken under the guidance of a doctor. During the medication period, you should take adequate rest and avoid driving a motor vehicle, as well as skiing, bungee jumping, diving and other sports that are prone to injury.

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