氨己烯酸口服溶液用散儿童使用的安全性怎么样？

Vigabatrin oral solution powder is safe for use by children, with a low incidence of serious side effects. However, children may experience some adverse reactions during medication, such as irritability and irritability. The specific manifestations vary from person to person. If any abnormality occurs in children during treatment, they should consult a doctor in time and deal with it through drug treatment, adjustment of medication regimen and other methods under the guidance of the doctor.

Safety of vigabatrin oral solution powder

The safety is good, and the incidence of serious side effects is generally low. In patients with infantile spasms, the most common adverse reactions associated with discontinuation of vigabatrin oral solution in >1% of patients were infection, status epilepticus, developmental coordination disorder, dystonia, hypotonia, hypertonia, weight gain, and insomnia.

Common adverse reactions include bronchitis, vomiting, diarrhea, fever, infection, irritability, insomnia, shock, strabismus, ear infection, otitis media, etc.

Methods for dealing with side effects

1. Bronchitis: If children develop bronchitis during medication, they can be treated with antibiotics under the guidance of a doctor, or with aerosol treatment. At the same time, drink plenty of water during treatment and keep the indoor air moist.

2. Ear infection: If the patient has symptoms of ear infection such as otitis media, symptomatic treatment can be provided. If the earache symptoms are severe, painkillers such as ibuprofen can be used to relieve the pain.

3. Irritability: If a child develops irritability symptoms after taking vigabatrin oral solution powder, such as mood changes such as restlessness or irritability. If the symptoms of irritability are mild, parents can try to observe their children and provide a quiet and comfortable environment. At the same time, under the advice of a doctor, they can alleviate emotional problems by adjusting the dosage or using other auxiliary means. If the symptoms of irritability are severe, the treatment plan can be changed or auxiliary psychological support can be added under the evaluation of a doctor.

The correct way to use vigabatrin powder for oral solution

You need to mix vigabatrin powder for oral solution with water and take the correct daily dose. Pour the entire contents of each 500 mg sachet into a clean cup and dissolve in 10 ml of cold or room temperature water per sachet. Inject the resulting solution using the 10 ml oral syringe provided with the medication. The concentration of the final solution is 50 mg/ml.

If the resulting solution is opaque (or particle-free) and colorless, discard it. Each individual dose should be prepared and used immediately and after using the correct dose, discard any unused portion of solution

Recommended Dosage for Infantile Spasms

A starting dose of 50 mg/kg daily (25 mg/kg twice daily). Increase the total daily dose every 3 days by increments of 25 mg/kg/day to 50 mg/kg/day, up to a maximum daily dose of 150 mg/kg (75 mg/kg twice daily).

The recommended dosage of the above drugs comes from the U.S. FDA drug instructions and is for reference only and does not serve as a medication guide. Patients should also follow their doctor's instructions when taking specific medications.

Precautions

1. Permanent loss of vision: Use of vigabatrin oral solution in powder form can cause permanent loss of vision. Because assessing vision in infants and children can be difficult, the frequency and extent of vision loss in these patients is difficult to describe. The possibility cannot be ruled out that vision loss caused by vigabatrin oral solution powder is more common, more severe, or has more serious functional consequences in infants and children than in adults.

2. Magnetic resonance imaging abnormalities in infants: Brain pictures taken by magnetic resonance imaging (MRI) show that some babies have changes after taking vigabatrin. It is not yet clear whether these changes are harmful.

3. Neurotoxicity: After treating young rats with vigabatrin oral solution and powder, long-term neurobehavioral abnormalities (convulsions, neuromotor disorders, and learning deficits) were also observed. After taking cowpea to puppies, vacuole-like changes appeared in the gray matter of the brain (including the septal nucleus, hippocampus, hypothalamus, thalamus, cerebellum and globus pallidus).

4. Risk of suicidal thoughts or behaviors: Like other anti-epileptic drugs, vigabatrin oral solution powder may cause suicidal thoughts or behaviors in a very small number of people. Therefore, if a child develops any unusual symptoms, he or she should consult a doctor promptly.

Summary

Vigabatrin oral solution powder, like other drugs, may cause adverse reactions in children. However, since each child's constitution is different, the adverse reactions will also be different. It is recommended that parents observe their children closely while taking the medicine and consult a doctor in time to deal with any abnormalities in their children.

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