司替戊醇说明书,医保,价格,疗效,副作用

Stiripentol is an anti-epileptic drug used to treat Dravet syndrome and is a gamma-aminobutyric acid (GABA)ergic drug. The drug controls epileptic seizures by enhancing the inhibitory effect of GABA and is mainly suitable for the treatment of refractory epilepsy in patients 2 years old and above. As an orphan drug, stiripentol has shown unique therapeutic effects in clinical applications.

Stipentol Instructions

Understanding the contents of the drug instructions is crucial to the correct use of this drug. The instructions contain key information on the use of the drug.

Indications and Dosage

Stipentol is approved for the treatment of epileptic seizures associated with Dravet syndrome. The recommended starting dose is 50mg/kg per day, taken in 2-3 times, and the maximum dose does not exceed 100mg/kg/day. Dosage adjustments must be made under the guidance of a physician.

Dosage forms and specifications

The original drug is available in 250 mg and 500 mg capsule forms. Domestic approved generic drugs are dry suspensions, each containing 250mg and need to be mixed with water when used.

Since stiripentol has not yet been officially launched in China, it is difficult for patients to obtain the original drug. The medical insurance and price of this drug will be introduced below.

Stipentol medical insurance and price

As a drug for rare diseases, the price and medical insurance policy of stiripentol are the focus of attention of patients.

Reimbursement status of medical insurance

Currently, domestically produced generic stiripentol dry suspension has been included in the scope of medical insurance reimbursement, and the reimbursement ratio varies from place to place. The original drug has not yet entered the national medical insurance catalog, and some provinces and cities have included it in local supplementary medical insurance.

Drug price information

The original drug stiripentol produced by Biocodex in France is available in two specifications: the price of 250mg*60 pills is about US$384, and the price of 500mg*60 pills is about US$617. The export price of the German version of the original drug is slightly higher, with the price of a 250mg*60 package being approximately US$453, and the price of a 500mg*60 package being approximately US$823.

After understanding the price of the drug, patients are more concerned about its actual therapeutic effect. The clinical efficacy of stiripentol will be introduced in detail below.

Efficacy and Side Effects of Stipentol

Stipentol has shown significant effects in controlling certain types of epileptic seizures, but there are also some adverse reactions that need to be noted.

Clinical treatment effect

Research shows that the frequency of seizures in most patients with Dravet syndrome is reduced by more than 50% after using stiripentol. The effect is better when used in combination with sodium valproate, and some patients can achieve long-term seizure freedom.

Common adverse reactions

Main side effects include decreased appetite, weight loss, drowsiness, etc. About 15% of patients may have abnormal liver function and require regular monitoring. A few patients may experience allergic reactions such as rash.

Pregnant women need to assess risks before use, and lactating women should suspend breastfeeding. The dosage for children should be calculated strictly based on body weight, and the dosage for elderly patients should be appropriately reduced. Avoid driving and operating machinery while taking this medication.