司替戊醇多少钱一盒

Stipentol is a new anti-epileptic drug specially used to treat rare and severe epilepsy. Its price, purchasing channels and pharmacological properties are the focus of patients' attention. This article will introduce in detail the market price, formal purchase channels, and pharmacokinetic characteristics of this drug to provide patients with comprehensive medication reference information.

How much does a box of stiripentol cost?

As an orphan drug, the price is relatively high, and the prices of drugs of different specifications and origins vary significantly. Understanding the specific prices can help patients make a good medication budget.

Original drug price

The original drug produced by Biocodex in France is priced at approximately US$384 for 250mg*60 capsules and approximately US$617 for 500mg*60 capsules. The German version is more expensive, about $453 for a 250mg package and $823 for a 500mg package.

Domestic generic drug prices

The price of domestically approved stiripentol dry suspension 250mg/pack and 30 packs/box is about US$310.

Factors affecting price

Drug prices are affected by multiple factors such as specifications, origin, tariffs, and circulation links. Large-sized packaging is usually more cost-effective, and medical insurance reimbursement can significantly reduce patients’ actual expenses.

Patients can choose appropriate drug specifications and purchase channels based on their own financial status and treatment needs.

Where to buy stiripentol

Due to the special nature of the drug, stiripentol needs to be purchased through formal channels to ensure drug quality.

Domestic purchase channels

Patients can purchase domestic generic drugs at the neurology department of the hospital or designated pharmacies with the prescription of a specialist. A diagnosis certificate and special medication application materials are required.

How to purchase drugs overseas

Original drugs can be purchased through qualified cross-border medical platforms. Drugs can also be obtained through overseas medical treatment, drug purchase, etc. Complete prescriptions, diagnostic certificates and customs declaration materials must be prepared.

Precautions when purchasing medicine

It is necessary to verify the batch number, expiration date and packaging integrity of the medicine when purchasing. Keep the drug purchase receipt to facilitate subsequent medication consultation and adverse reaction reporting.

With the launch of domestic generic drugs, the convenience for patients to purchase drugs has significantly improved. It is recommended to give priority to domestic formal channels.

Pharmacokinetics of stiripentol

Understanding the pharmacokinetics characteristics of stiripentol is of great significance for rational drug use.

Absorption and Distribution

Plasma peak is reached 1-3 hours after oral administration, and the bioavailability is about 90%. A high-fat diet may increase absorption. The protein binding rate is about 99% and it is mainly distributed in adipose tissue.

Metabolism and excretion

Metabolized by the liver CYP enzyme system, the half-life is about 10-15 hours. Metabolites are mainly excreted through the kidneys and a small amount through the feces.

Drug interactions

Combined use with sodium valproate may affect each other's metabolism, and the dose needs to be adjusted. Strong CYP inducers will reduce its plasma concentration, while inhibitors may increase the risk of adverse reactions.

Plasma concentration should be monitored regularly during medication, especially when combined medication or adverse reactions occur.