苯丁酸钠Ucyclyd的作用功效是什么？长期用有哪些副作用

Sodium phenylbutyrate Ucyclyd is a prodrug that is rapidly metabolized to phenylacetate. It can combine with glutamic acid and ammonia to form phenylacetylglutamine, which is excreted through the kidneys and is another chemicalbook pathway for the excretion of nitrogen-containing waste. Studies have found that sodium phenylbutyrate Ucyclyd is a histone deacetylase inhibitor with high efficiency and low toxicity, and can inhibit the growth of various tumor cells. What is the function of that? What are the side effects of long-term use?

Sodium phenylbutyrate Ucyclyd undergoes beta-oxidation in the body and is metabolized into phenyl acetate. Phenyl acetate is then conjugated with glutamine to form phenylacetyl glutamine. The above two-step reactions are both fast and complete. As a substitute for waste nitrogen product of urea, phenylacetyl glutamine can be excreted through the kidneys and is chemically equivalent to urea on a molar level. Each mole of both contains 2 moles of nitrogen. It is reported that when sodium phenylbutyrate Ucyclyd is used to treat patients with urea cycle disorders, blood ammonia and blood glutamate levels can be reduced or even reach normal levels.

Ucyclyd sodium phenylbutyrate side effects include: ankle and peripheral edema, blood pressure changes, headache, depression, hypoalbuminemia, metabolic acidosis, alkalosis, hyperchloremia, hyperuricemia, hypokalemia, hypophosphatemia, hyperphosphatemia, hypernatremia, irregular menstrual cycles in women, renal tubular acidosis, increased alkaline phosphatase levels, lack of appetite, nausea, vomiting, peptic ulcer, rectal bleeding, constipation, pancreatitis, thrombocytopenia, etc. If patients experience serious side effects during Ucyclyd treatment, they should go to the hospital in time and have a professional doctor adjust the medication plan. After patients have adverse reactions, they should not use other medications without authorization, as they may cause other side effects and affect their condition.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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