雷帕鸣何时上市？

When will Rapaming be launched? It is understood that sirolimus (sirolimus) was launched in Europe and the United States in 1999 and in China in 2003.

Rapamin (sirolimus) is a triene macrolide antibiotic extracted from the culture medium of Streptomyces. It is structurally homologous to FK506. Although it acts on the same receptor, their immune mechanisms are different. Sirolimus can block the calcium-dependent and calcium-independent signaling pathway P1 of T lymphocytes and B lymphocytes.

Rapamin (sirolimus tablets, sirolimus) and FK506 share the same receptor in the body, namely FK506 immunobinding protein (FKBP). After rapamin binds to FKBP, on the one hand, it inhibits the activation of 70-KSU6 kinase (p7), so that the ribosomal 40S subunit S6 protein cannot phosphorylate g7, affecting protein synthesis; on the other hand, it affects protein synthesis by inhibiting cyclin (Cyclin). The expression of D2, D3 and cell cycle-dependent kinases, namely cdk4 and cdk6, and the activation of Cyclin E-cdk2 complex make cells stagnant in the middle and late stages of GI and unable to continue to proliferate. Its direct target may be mTOR, a protein with a homologous sequence to phospholipid phthaloinositide kinase. That is, the combination product of the rapamycin and FKBP complex with mTOR can block the immune response triggered by activation of mTOR by H, -2, U, -15 or CD28/B7 costimulatory pathways, thereby exerting a powerful immunosuppressive effect.

According to Medical Travel, the cheapest product currently available is Sirolimus (sirolimus) sold abroad, which is priced at about $1,800 per box. Since the exchange rate fluctuates and the price is not fixed, please consult the medical companion passenger service for specific prices.