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It is another name for sirolimus. The tablets are triangular sugar-coated tablets. Other preparations include capsules, oral solutions, etc. Rapamin is a prescription drug for use only by physicians experienced with immunosuppressive therapy and managing kidney transplant patients. In clinical trials, the use of rapamycin can effectively prolong the survival of patients after transplantation and reduce the occurrence of acute rejection.

Rapamin sirolimus tablets are recommended to be taken orally once daily in combination with cyclosporine and corticosteroids. To reduce differences in the absorption of rapamycin, patients should choose to take it regularly with or without food. Tablets should not be broken or chewed.

Experimental studies have found that rapamycin does not inhibit calcineurin after binding to cytoplasmic proteins, so it can completely avoid the nephrotoxicity of calcineurin inhibitors (CNI). It is one of the best choices when liver or renal insufficiency occurs after organ transplantation or when CNI cannot reach the ideal drug concentration.

Many patients want to know how long it will take for rapamin sirolimus tablets to take effect, which depends on the patient's own situation. Rapamin should be started as soon as possible after transplantation. It is recommended that rapamycin should be taken 4 hours after taking cyclosporine oral solution (modified) and/or cyclosporine capsules (modified) [cyclosporine microemulsion (modified)].

For newly transplanted patients, the recommended usage and dosage of rapamin is as follows: the loading dose of rapamin should be taken for the first time, that is, 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Moreover, the patient's blood concentration of therapeutic drugs needs to be monitored during the treatment process.

Sirolimus tablets, as a macrolide compound, are potentially new and potent immunosuppressants with less toxicity discovered so far, providing a new treatment alternative for transplant recipients. Patients need to follow the doctor's instructions carefully and use the medicine in the correct way during the treatment process.

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