可以长期用雷帕鸣来预防肾移植后出现的器官排斥吗

Can it be used long-term to prevent organ rejection after kidney transplantation? Rapamin, also known as sirolimus, is approved for the treatment of kidney transplant patients aged 13 or above to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids.

In a study conducted in China, patients' renal function improved after switching therapy. The results suggest that rapamycin is more effective than tacrolimus (FK506) in switching treatment. The immunosuppressive treatment regimen based on rapamycin (sirolimus) is safe and effective for patients with progressive increase in serum creatinine caused by the use of tacrolimus.

Rapamin (sirolimus) is available in tablets, capsules, oral solution and other dosage forms. Rapamin tablets should only be used by physicians experienced in immunosuppressive therapy and handling kidney transplant patients. Patients should not take medication blindly. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Rapamide can be taken with or without food, but the tablets should not be broken or chewed. If the patient has difficulty swallowing, an oral solution should be chosen. If dosage adjustment is necessary, this should be done on the advice of a physician.

Rapamin (sirolimus) may have some side effects or develop drug resistance if used for a long time. Common side effects include thrombocytopenia, anemia, fever, hypokalemia, hypophosphatemia, hypertension, urinary tract infection, hypercholesterolemia, hyperglycemia, hypertriglyceridemia, lymphocele, pain, joint pain, acne, peripheral edema, abdominal pain, diarrhea, constipation, nausea, headache, elevated blood creatinine levels, and elevated blood lactate dehydrogenase levels (LDH).

When serious side effects occur when using (sirolimus), patients need to contact their doctor promptly and adjust or change their medication under the doctor's diagnosis.

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