孕妇能不能服用雷帕鸣西罗莫司片

Each medicine is developed according to different symptoms. It does not mean that all symptoms can be taken. Different people take it for different symptoms. If it is safe, there will be no side effects. However, it will not be good if the person who takes it worsens his condition because he does not take it according to the symptoms. So, can (sirolimus) be taken by pregnant women?

Rapamin (sirolimus) is contraindicated in patients who are allergic to sirolimus, sirolimus derivatives, or any component of this drug's oral solution, as well as pregnant and lactating women. Grapefruit juice slows the metabolism of this drug, which is regulated by CYP3A4, and should not be used to administer or dilute this drug. It is recommended to take sirolimus 4 hours after taking cyclosporine oral solution (modified version) and/or cyclosporine capsules (modified version).

Different conditions require different treatment courses. However, the drug has side effects, and any drug is not suitable for long-term use. Adverse reactions include side effects and toxic reactions. Side effects are inherent and unavoidable with drugs, but they are not harmful. Toxic effects are very harmful and can be avoided. Long-term use will cause toxic effects, so it is recommended that you do not take certain drugs, including rapamycin (sirolimus), for a long time.

Rapamin (sirolimus) is rapidly absorbed from oral solution, with the average time to peak after a single oral dose being approximately 1 hour; in kidney transplant recipients, the average time to peak after multiple oral doses is approximately 2 hours. High-fat meals can increase the absorption of rapamin (sirolimus), so it is recommended that oral rapamin (sirolimus) should be taken regularly with or without food.

Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the efficacy benefit of doses above 2 mg in renal transplant patients is unclear. The overall safety profile of patients taking rapamycin (sirolimus) oral solution 2 mg daily was better than that of patients taking 5 mg oral solution daily.

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