雷帕鸣服用后多久见效？

It is an immunosuppressant drug mainly provided to organ recipients for organ transplant surgery. It is a bacterial species derived from Streptomyces hygroscopicus and is often used to prevent organ rejection after kidney transplant surgery. Since long-term use brings less toxicity and side effects to the kidneys, it is a more popular immunosuppressant. How long does it take for rapamycin to take effect after taking it?

The effective time of Rapamin depends on the patient's own disease. Due to individual differences, the effective time of each person is different!

Rapa Ming User Guide:

1. It is recommended that rapamycin be used in combination with cyclosporine and corticosteroids. Lepamin is taken orally, once a day. Rapamin should be started as soon as possible after transplantation. For new transplant recipients, the loading dose of rapamin should be taken for the first time, that is, 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients. The overall safety profile of patients taking 2 mg of rapamide daily was better than that of patients taking 5 mg rapamide daily. To minimize differences in the absorption of rapamin, rapamin should be taken consistently with or without food.

2. Dose adjustment: For patients over 13 years old but weighing no more than 40kg, the starting dose should be adjusted to 1mg/m2/day based on the body surface area, and the loading dose should be 3mg/m2. It is recommended that the maintenance dose of rapamin in patients with hepatic impairment be reduced by approximately 1/3, but no adjustment to the loading dose is required. Pharmacokinetic studies have not been performed in patients with severe hepatic impairment. No dosage adjustment is required in patients with renal impairment.

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