What disease does raloxifene treat best? What is the efficacy and role of raloxifene

Raloxifene is a benthiophene compound, a new concept non-hormonal drug that resists bone resorption, and is a second-generation selective estrogen receptor modulator (SERM). SERMs can act as estrogen agonists or antagonists. What disease is best to treat? What are the effects and effects of raloxifene?

Indications for raloxifene

Raloxifene is mainly used to prevent and treat osteoporosis in postmenopausal women. It can significantly reduce the incidence of vertebral fractures, but the reduction in the incidence of hip fractures has not been confirmed.

Raloxifene effects and efficacy

Raloxifene has an estrogen agonistic effect on the bones and cardiovascular system, and an estrogen antagonistic effect on the breast and uterus without many adverse reactions of estrogen. It can increase bone mineral density and prevent postmenopausal bone loss; it reduces total cholesterol, low-density lipoprotein cholesterol (LDL-C), fibrinogen and lipoprotein A levels, without affecting triglycerides and high-density lipoprotein cholesterol (HDL-C); it does not stimulate the breast and endometrium, and does not increase the risk of breast cancer and endometrial cancer.

Raloxifene is called a "selective estrogen receptor modulator" by the medical community. In layman's terms, the so-called "selective estrogen receptor modulator" means that it has a stimulating effect on the estrogen receptors of some tissues or organs (such as bones), while it has an inhibitory effect on the estrogen receptors of other tissues or organs (such as the breast and uterus).

The MORE trial selected 7705 postmenopausal women with osteoporosis and followed them for 48 months. The trial results confirmed that taking raloxifene can significantly reduce the risk of vertebral fractures. After taking raloxifene for 1 year, the risk of vertebral fractures dropped by 68%; after taking raloxifene for 4 years, the risk of vertebral fractures dropped by 50%. According to the MORE study, the relative risk of breast cancer in raloxifene users was 70% lower than that in the control group. It can be seen that the therapeutic effect of raloxifene is very significant, and the successful development of this drug is good news for many patients.

Raloxifene side effects

Common side effects of raloxifene include: vasodilation (hot flashes), venous thromboembolic events: including deep vein thrombosis, pulmonary embolism, retinal vein thrombosis, superficial vein thrombophlebitis, calf cramps, influenza symptoms, peripheral edema, thrombocytopenia, nausea, vomiting, abdominal pain, indigestion, rash, mild breast symptoms, etc. Patients should not use raloxifene blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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