雷洛昔芬作用机制,雷洛昔芬是什么药？

Raloxifene can reduce total cholesterol, low-density lipoprotein cholesterol (LDL-C), fibrinogen and lipoprotein A levels, but does not affect triglycerides and high-density lipoprotein cholesterol (HDL-C). The drug does not stimulate the breast and endometrium, and does not increase the risk of breast cancer and endometrial cancer. What's the mechanism of action? What is raloxifene?

Indications for raloxifene

Raloxifene is an anti-osteoporosis drug, mainly suitable for postmenopausal women with osteoporosis. Some studies have reported that Raloxifene can significantly reduce the incidence of spinal vertebral fractures, but there is no clear evidence that it can reduce the incidence of fractures in the hip joint and other parts.

Raloxifene mechanism of action

Raloxifene is a selective estrogen receptor modulator that activates certain estrogen pathways and blocks other pathways after binding to estrogen receptors. Raloxifene has an estrogen agonistic effect on the bones and cardiovascular system, and an estrogen antagonistic effect on the breasts and uterus. It does not have many adverse reactions of estrogen. Raloxifene can increase bone mineral density and prevent postmenopausal bone loss.

Raloxifene side effects

Side effects of Raloxifene include: vasodilation, venous thromboembolic events, calf cramps, influenza symptoms, peripheral edema, thrombocytopenia, nausea, vomiting, abdominal pain, indigestion, increased blood pressure, headache, rash, etc. Since each patient's physical fitness and tolerance to drugs are different, the time for side effects to appear is also different. Patients should strictly follow the doctor's instructions during treatment with Raloxifene. When unbearable serious side effects occur, they need to stop taking the drug and seek medical treatment in time.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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