一年只要打一次的抗骨质疏松神药-唑来膦酸

Osteoporosis is a chronic metabolic bone disease whose main clinical characteristics are low bone mass and degenerative changes in bone tissue microstructure. Patients often experience increased bone fragility and are prone to fractures, which are more common in the elderly and postmenopausal women, resulting in adverse effects on the patient's healthy life. It is said to be an anti-osteoporosis miracle drug that only needs to be taken once a year. Is it really so miraculous?

Zoledronic acid is a third-generation bisphosphonate drug. Its clinical indications include malignant hypercalcemia, postmenopausal osteoporosis, malignant tumor bone metastasis, etc. Studies have confirmed that zoledronic acid has a high affinity for the mineralized surface of bone, especially the active parts of bone turnover, and many drugs can maintain a certain blood concentration after sustained release.

Zoledronic acid is currently the most pharmacologically active bisphosphonate drug. Compared with similar drugs, it has a stronger ability to bind hydroxyapatite. Zoledronic acid only needs to be administered once a year and is more convenient to use. However, it has potential anti-angiogenic effects and can reduce the blood supply to the damaged site. Therefore, whether the use of zoledronic acid will reduce the blood supply to the fracture site and thereby affect fracture healing is one of the clinical controversies. However, some studies have reported that zoledronic acid does not affect the fusion rate of spinal bone grafting and does not cause delayed healing or nonunion of fractures.

In 2007, two studies published in the world's top medical journal "The New England Journal of Medicine" demonstrated the wonders of zoledronic acid. The drug only requires intravenous infusion and does not require long-term oral administration, thus avoiding some of the side effects of oral drugs on the gastrointestinal tract. Zoledronic acid only needs to be applied once a year, which greatly simplifies the clinical osteoporosis treatment plan. This medicine has been used continuously for three years, during which time it is supplemented with appropriate amounts of calcium and vitamin D. It is effective in maintaining bone mass and reducing the incidence of osteoporotic fractures.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.