持续抗击骨质疏松只需每年一次-唑来膦酸就这么神！

Osteoporosis is a metabolic bone disease with a high incidence rate, with reduced bone mass, increased bone fragility, and changes in bone structure as its main pathological manifestations. All types of people can suffer from osteoporosis, but the elderly have higher disability and mortality rates. (Zoledronic Acid) is a bisphosphonate anti-osteoporosis drug that inhibits bone resorption. The drug only needs to be used once a year to combat osteoporosis. It can be said to be a very miraculous drug.

Zoledronic Acid is a bisphosphonate preparation that can be used in the treatment of many different types of osteoporosis. It can quickly diffuse to the bone surface and has strong bone mineral salt binding ability. It inhibits bone resorption and osteoclast function, repairs damaged trabeculae, and thus inhibits bone lesions. In addition, zoledronic acid can block the mevalonate pathway, promote osteoclast apoptosis, inhibit the absorption of mineralized bone and cartilage by osteoclasts, and block the release of bone calcium induced by various stimulating factors, thereby increasing bone density.

Zoledronic acid blocks the mevalonate pathway in osteoclasts, inhibits farnesyl pyrophosphate synthase, accelerates cell apoptosis, reduces the synthesis and release of β-CTX, and improves bone metabolism. In the study, zoledronic acid was used to treat postmenopausal women with osteoporosis. After a one-month follow-up, it was found that none of the patients had fractures or serious damage to heart, liver and kidney function. Only fever and mild joint and muscle pain occurred. After short-term symptomatic treatment, they returned to normal, indicating that the safety of zoledronic acid is relatively high.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.